BackgroundAdolescence is a critical period for developing and maintaining good habits for mental health and well-being. This is crucial for future mental health; as most mental health problems emerge during adolescence. Mental health literacy forms the foundation for preventing mental health issues, reducing stigma, and enhancing the effectiveness of help-seeking, particularly among adolescents.ObjectiveThis study aims to measure the effect of social media-based educational intervention on mental health literacy among male high school students in Ramhormoz city.MethodsThis randomized controlled trial (RCT) evaluated the effectiveness of a social media-based intervention, designed around the core components of The Guide training package. The study involves all high schools in Ramhormoz city using a stratified random sampling method. A total of 204 students are expected to participate. Measures of mental health literacy and attitudes towards seeking professional psychological help are evaluated at three time points: before the intervention (baseline), 3 months, and 6 months after the intervention.ResultsWe anticipate a significant improvement in the mental health literacy score of the intervention group compared to the control group at post-intervention and both follow-ups. Additionally, we expect a substantial enhancement in the attitude towards seeking professional psychological help score for the intervention group compared to the control group at post-intervention and 6-month follow-up, though not at the 3-month follow-up.ConclusionIn conclusion, this study will contribute valuable insights into the effectiveness of social media-based interventions in enhancing mental health literacy and attitudes towards seeking professional help among high school students. The results will guide future initiatives in mental health education and promotion.Clinical trialsThis study protocol is registered with the Iranian Registry of Clinical Trials (IRCT) under the registration number IRCT20230603058372N1, dated June 5, 2023. The study adheres to the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) guidelines, as outlined in Supplementary File S1.