Stress at work place is a barometer of the health of an organization. Prolonged stress in any employee leads to professional burnout. This study examined the relationship between professional burnout and occupational stress due to personal & professional efficiency of teachers working at university level. Rating Scales were administered on a sample of 955 university teachers from 9 universities of Andhra Pradesh and Tamil Nadu who were chosen by using Simple Random Sampling Technique. The statistical techniques employed were percentage, mean, SD, mean ± 1SD, and also correlations computed to analyze the obtained data. Results of the study revealed that around 86% of university teachers are experiencing moderate and high levels of professional burnout and around 60% of them are showing moderate level of occupational stress due to personal & professional efficiency. Further, correlation studies revealed that there is a significant positive relationship between professional burnout and occupational stress due to personal & professional efficiency. The results reinforce the need for interventions in strengthening and reinforcing teacher’s self-confidence and positive attitude, and weakening the stress and burnout causing factors. Much of the stress and burnout can be minimized through support, persistence, problem solving, active decision making and planning, organizational adaptability and developing good human relations.