Interpersonal relationships can have a significant impact on students' educational experience, and positive relationships can foster a sense of community, mutual support, and collaboration, which can improve students' academic performance and motivation. The study aimed to determine the effectiveness of the implementation of the "Predeco" program on high school students' interpersonal relationships in 2021. The study followed the quantitative approach and pre-experimental design. The sample consisted of 30 students selected from a non-probabilistic sampling, to whom a questionnaire validated by experts and subjected to reliability criteria was applied. The results show that the application of the "Predeco" program significantly improved (p=0.000000875<0.05) the interpersonal relationships of the participants. Meanwhile, the program significantly influenced the dimensions Self-Control (p=0.000000745<0.05), Assertiveness (p=0.000000806<0.05), Empathy (p=0.000000843<0.05) and Teamwork (p=0.000000814<0.05). It was concluded that the program had a positive impact on interpersonal relationships and, therefore, on the improvement of the students' reciprocal interaction. The study provides empirical evidence of how entrepreneurship and innovation in education can contribute to the improvement of students' interpersonal skills.