Studi Monitoring Efek Samping Obat Antituberkulosis FDC Kategori 1 Di Provinsi Banten Dan Provinsi Jawa Barat

Sari, Ida Diana; Yuniar, Yuyun; Syaripuddin, Muhamad

doi:10.22435/mpk.v24i1.3484.28-35

Cited by 19 publications

(19 citation statements)

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“…Based on the observation on weight changes, there was a strong indication that intensive Propolis suplementation for pulmonary tuberculosis patients use of ATDs caused a decrease in BW through the hepatotoxic mechanism. Hepatotoxic effects includes decreased in appetite, nausea and dizziness (Sari et al 2014), thus the food intake decreased drastically that led to weight loss. The weight recovery was noticeable after entering continuation treatment period (the 9 th week until the 24 th week), either in the group not receiving propolis supplementation (P0) or the groups receiving propolis supplementation (P1 and P2).…”

Section: Body Weight (Bw)mentioning

confidence: 99%

“…One of the problems faced in the use of ATDs to date is its hepatotoxic properties (Chowdhury et al 2006;WHO 2013). The hepatotoxic effects of ATDs can cause decrease in appetite, nausea, dizziness, insomnia, fever and weight loss (Kemenkes 2009;Sudarsanam & Tharyan 2014;Sari et al 2014). These hepatotoxic effects further cause decline in nutritional status of the patients, whereas good nutritional status strongly supports cure (Semba & Bloem 2001).…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of propolis supplementation to accelerate healing process and body weight recovery of pulmonary tuberculosis patients

et al. 2018

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This study aimed to evaluate the pace of curing process and body weight recovery of pulmonary tuberculosis (Tb) patients receiving propolis supplementation. This study was a randomized controlled trial conducted on 50 pulmonary Tb patients that were assigned into three groups as follows: receiving standard-dose antituberculosis drugs (ATDs) + 20 drops of placebo propolis (P0); receiving standarddose ATDs + 20 drops of propolis with concentration of 6% (P1); and receiving standard-dose ATDs + 20 drops of propolis with concentration of 30% (P2). The results showed that the mean time ratio needed for sputum smear conversion to negative present of acid resitant bacteria in P0, P1 and P2 groups were weeks 10, 8 and 5, respectively. In the second week, mean body weight of P0 and P1 groups decreased by 2.4% and 0.2%, respectively. In contrast, the mean body weight in P2 group increased by 1.5% (p<0.05; Mann-Whitney test). In the same week, mean body mass index (BMI) of P0 and P1 groups decreased by 1.6 and 0.1, respectively. Conversely, the mean BMI of P2 group increased by 0.3. The changes were significantly different (p<0.05). The results conclusively indicated that supplementation of 20 drops of propolis with a concentration of 30% as an adjuvant to standard ATDs for the treatment of pulmonary Tb patients was beneficial to accelerate treatment effect and body weight recovery.

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Section: Body Weight (Bw)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy of propolis supplementation to accelerate healing process and body weight recovery of pulmonary tuberculosis patients

et al. 2018

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“…2 Tuberculosis is actually a disease that can be treated with intensive and comprehensive treatment. 3 The challenges from this treatment are that antituberculosis (anti-TB) drugs could cause multidrug resistance (MDR) and some adverse effects, including hepatotoxicity. Hepatotoxicity is one of the anti-TB drugs adverse effects.…”

Section: Introductionmentioning

confidence: 99%

“…Hepatotoxicity is one of the anti-TB drugs adverse effects. 3,4 It is a liver dysfunction or liver damage that correlates to drug dosage or xenobiotic. 5 Anti-TB drugs that cause hepatotoxicity include Isoniazid, rifampicin, pyrazinamide, and ethambutol.…”

Section: Introductionmentioning

confidence: 99%

Effect of Anti-tuberculosis Drugs on Liver Damage Based on Alanine Aminotransferase Level in Pulmonary Tuberculosis Patients

Dianwari

Yunivita

Kania

2017

amj

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Background: Antituberculosis (anti-TB) drugs could cause serious effect such as hepatotoxicity signed by the increase of Alanine Aminotransferase (ALT) level. Anti-TB drugs are still needed by TB patients who have hepatotoxicity, although clinicians who manage this condition have not recognize whether the advantage of anti-TB drugs is higher than its adverse effect, and there is no data describing about that issue. This study was conducted to discover the liver damage based on the ALT changes before and 12 days after initial anti-TB treatment. Methods: This was a cross-sectional study with total sampling of medical records of pulmonary tuberculosis inpatients from 1st January 2013-31th December 2014 at the Department of Internal Medicine of Dr. Hasan Sadikin.General Hospital. From 141 data, only 14 medical records were eligible to be included in this study. The data used were ALT level before and after therapy. These data were analyzed using Wilcoxon test and considered as significant if p<0.05. Results: The median age of the subject study was 48(18-65) years. Among 14 patients, 8 were female and 6 were male. Five out of fourteen patients developed hepatotoxicity. Four out of five developed grade 1 hepatotoxicity and one out of five developed hepatotoxicity grade 4. The analysis of the data showed the differences of ALT level before anti-TB therapy (22(4-447)) and 12 days after initial therapy (18.5(4-1206)) was not significant (p=0.660). Conclusions: There is no liver damage based on ALT changes after anti-TB treatment so the treatment can be continued.

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“…Terlebih lagi pada pasien anak yang fungsi organnya belum bekerja sempurna, efek samping obat sangat mungkin terjadi. 5 Hepatotoksisitas merupakan efek samping paling banyak terjadi pada pemberian obat anti tuberkulosis (OAT) atau biasa disebuh dengan anti-tuberculosis drug induced hepatotoxicity (ADIH), 7% dari semua efek samping disebabkan oleh OAT. 6 Toksisitas akan meningkat ketika obat ini dikombinasikan.…”

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Profil Pasien Tuberkulosis Anak dengan Anti-tuberculosis Drug Induced Hepatotoxicity di Rumah Sakit Umum Pusat Dr. Hasan Sadikin Bandung

Shafira

Sudarwati

Alam

2018

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Latar belakang. Dalam pengobatan tuberkulosis anak diperlukan kombinasi obat, seperti isoniazid, rifampisin, dan pirazinamid. Ketiga obat ini dapat menimbulkan efek samping berupa anti-tuberculosis drug induced hepatotoxicity (ADIH). Tujuan. Penelitian ini bertujuan untuk mengetahui profil pasien tuberkulosis (TB) anak dengan ADIH. Metode. Penelitian ini merupakan penelitian deskriptif kuantitatif potong lintang. Data diambil dengan metode total sampling dari rekam medis pasien TB anak yang mengalami gejala hepatotoksisitas dan telah menjalani pengobatan di RSUP Dr. Hasan Sadikin Bandung, dari Januari 2014-Mei 2017. Hasil. Di antara 709 pasien TB anak di RSHS, 48 pasien mengalami ADIH. Enampuluh satu persen pasien berusia ≤5 tahun, terdiri atas 15 laki-laki dan 21 perempuan, 24 (67%) pasien mengalami gizi buruk. Duapuluh delapan pasien (78%) mengalami ikterus, 17 (47%) mengalami mual muntah, 24 (67%) ditemukan hepatomegali. Peningkatan SGPT ditemukan pada 25 (69%) pasien. Tujuhpuluh empat pasien mengalami peningkatan bilirubin ≥1 U/L. Seluruh pasien ADIH dihentikan terapinya. Enampuluh tujuh persen kasus ADIH timbul di fase awal terapi obat anti tuberkulosis (OAT) dan 56% pasien membaik selama 15-30 hari. Kesimpulan. Gejala ADIH yang muncul pada anak berupa ikterus, mual dan muntah. Dari pemeriksaan fisik, sebagian besar mengalami hepatomegali. Pada pemeriksaan fungsi liver, terjadi peningkatan SGOT/SGPT dan bilirubin. Gejala ADIH kebanyakan muncul di fase awal terapi OAT. Sari Pediatri 2018;19 (5) Objective. This research aims to discover ADIH in TB pediatric patients. Methods. This research used quantitative descriptive cross-sectional study as method. Data was collected by total sampling method from the pediatric tuberculosis medical record showing hepatotoxic sign, treated in RSUP Dr. Hasan Sadikin Bandung, from January 2014 to May 2017. Result. Of 709 patients, 48 were diagnosed with ADIH. Approximately 61% cases occurred in pediatric age ≤5, consist of 15 males and 21 females. 24 of them (67% patient), had malnutrition. 28 patients (78%) were experiencing icterus, 17 (47%) experiencing nausea and vomiting, and 24 (67%) diagnosed with hepatomegaly. SGPT levels elevation occurred in 25 patients (69%). Bilirubin elevation ≥ 1 U/L occurs in 74% patients. All patients got their treatment terminated. In 67% cases, ADIH occurred in early phase of therapy. 56% of them improved in 15-30 days. Conclusion. Signs of ADIH in pediatrics are icterus, nausea, and vomiting, while hepatomegaly appeared mostly in physical examination. In liver function test, SGOT/SGPT and bilirubin levels elevated. Those signs mostly occurred in early phase of therapy.

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Studi Monitoring Efek Samping Obat Antituberkulosis FDC Kategori 1 Di Provinsi Banten Dan Provinsi Jawa Barat

Cited by 19 publications

References 0 publications

Efficacy of propolis supplementation to accelerate healing process and body weight recovery of pulmonary tuberculosis patients

Efficacy of propolis supplementation to accelerate healing process and body weight recovery of pulmonary tuberculosis patients

Effect of Anti-tuberculosis Drugs on Liver Damage Based on Alanine Aminotransferase Level in Pulmonary Tuberculosis Patients

Profil Pasien Tuberkulosis Anak dengan Anti-tuberculosis Drug Induced Hepatotoxicity di Rumah Sakit Umum Pusat Dr. Hasan Sadikin Bandung

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