Studien über Beziehungen zwischen Rhodanbildung und kropfbildender Eigenschaft von Nahrungsmitteln, I. Gehalt einiger Nahrungsmittel an präformiertem Rhodanid

Michajlovskij, N; Langer, P

doi:10.1515/bchm2.1958.312.1.26

Cited by 54 publications

(15 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SCN concentration was measured in cord serum in all 82 subjects, using the method of Michajlovskij & Langer (1958). A SCN value <35 μmol/l was considered as a control value (Delange et al 1982).…”

Section: Methodsmentioning

confidence: 99%

Smoking during pregnancy: a significant cause of neonatal thyroid enlargement

Chanoine

Toppet

Bourdoux

et al. 1991

BJOG

View full text Add to dashboard Cite

Summary. The influence of maternal smoking during pregnancy on the function and the echographic volume of the neonatal thyroid gland was examined in an area of borderline iodine intake (median maternal urinary iodine: 315 range 79–1558 nmol/l). There was a positive correlation (P<0.001) between cord serum thiocyanate (SCN) concentrations used as an index of maternal smoking and the maternal smoking habits. The thyroid volume/birthweight ratio increased significantly as a function of SCN values (P<0.005): this increase was secondary to a decrease in birthweight as well as to an increase in thyroid volume. There was also a positive correlation between cord serum thyroglobulin (Tg) and SCN levels (P = 0.001). Serum thyroid‐stimulating hormone (TSH) and free thyroxine (FT4) values remained within the normal range for age in all newborn infants and were not significantly correlated with SCN values. These results show that smoking during pregnancy in areas with borderline iodine intake may be a significant cause of thyroid enlargement in the newborn.

show abstract

Section: Methodsmentioning

confidence: 99%

Smoking during pregnancy: a significant cause of neonatal thyroid enlargement

Chanoine

Toppet

Bourdoux

et al. 1991

BJOG

View full text Add to dashboard Cite

show abstract

“…After incubation 2 ml of 96% (w/v) trichloroacetic acid solution were added and the solution was diluted to 20 ml with distilled water and centrifuged at 48,000g for 10 min to precipitate the enzyme. Two-milliliter aliquots from the supernatant were used for estimation of thiocyanate by the method of Aldridge (1) as modified by Michajlovskij and Langer (27). The blank was prepared in exactly the same way but the myrosinase solution was replaced by 1 ml of distilled water.…”

Section: Methodsmentioning

confidence: 99%

Distribution and Variation of Indole Glucosinolates in Woad (Isatis tinctoria L.)

Elliott

Stowe

1971

Plant Physiol.

View full text Add to dashboard Cite

The exceptionally high levels in woad (Isatis tinctoria L.) of three indolic goitrogens, namely glucobrassicin, neoglucobrassicin, and glucobrassicin-l-sulfonate, permit the facile study of their distribution in the plant and their changes during its development. Woad seeds contain as much as 0.23 % fresh weight of glucobrassicin but no other indole glucosinolate, while 1-week-old seedlings also contain substantial amounts of neoglucobrassicin and glucobrassicin-l-sulfonate in their shoots whether grown in the light or dark. The sulfonate is not found in roots, and light depresses neoglucobrassicin levels in shoots. Sterile root cultures synthesize glucobrassicin and neoglucobrassicin, and significant quantities of these were even found to be excreted by the roots of intact sterile seedlings in culture. This may explain the long known deleterious effect of woad and other cruciferous crops on subsequent plantings and the observation could be of ecological importance. Long term changes in levels of all three substances in the plant are similar and are compatible with earlier suggestions that the compounds could be auxin precursors at the time of flower stem elongation. Since sterile seedlings readily incorporate 3SO42-into indole glucosinolates and relative specific radioactivities suggest that glucobrassicin is the precursor of the other two compounds, pathways of goitrogen biosynthesis should be relatively easily determined in this material.In previous papers (9, 10) of the plant (e.g., during very rapid growth such as "bolting" of the flower shoot).Animal nutrition is influenced by indole glucosinolates due to the fact that the enzyme myrosinase (which is released from special cells in the plant tissues upon crushing) acts to release the goitrogenic thiocyanate ion from them (10, 41). In areas where large quantities of brassicaceous crops are eaten or fed to cows (which transfer part of the thiocyanate to their milk) these thiocyanate ions are at least partially responsible for endemic goiter in the human population (Ref. 28 and references therein).Finally, the distribution of indole glucosinolates in the plant kingdom has provided useful information for chemotaxonomic considerations (1 1. 31, 33).As the woad plant has exceptionally high levels of three indole glucosinolates, its study should cast light on these topics. We have examined the changes which occur in the levels of each of the indole glucosinolates in the shoots and roots of woad plants during germination, growth, and flowering. A similar study with the mustard plant (Sinapis alba L.) has recently been published by Bergmann (3). MATERIALS AND METHODSPlant Material. Seeds of woad (l. tinctoria L.) were collected from plants which had flowered in Yale University's Marsh Botanic Garden in 1967 and had been stored at room temperature over the winter. The field-grown woad plants were obtained from the crop produced by sowing these seeds in the spring of 1968.For sterile culture, seeds were dissected out of the fruits, sterilized as described pr...

show abstract

“…Thiocyanate content in urine was measured from the collected urine samples used for the analysis of iodine by the method of Aldridge 14 and modified by Michajlovskij and Langer 15 . The iodine/thiocyanate ratio (I/SCN) was calculated by the division of each iodine concentration (\ig/dl·) by the same sample's thiocyanate concentration (mg/dl).…”

Section: Thiocyanate In Urine/consumption Pattern Of Common Goitrogenmentioning

confidence: 99%

Etiological Factors for the Persistence of Endemic Goiter in Selected Areas of Siddharthnagar District in Eastern Uttar Pradesh, India

Chandra

Bhattacharjee²,

Malik³

et al. 2009

Journal of Pediatric Endocrinology and Metabolism

View full text Add to dashboard Cite

show abstract

Studien über Beziehungen zwischen Rhodanbildung und kropfbildender Eigenschaft von Nahrungsmitteln, I. Gehalt einiger Nahrungsmittel an präformiertem Rhodanid

Cited by 54 publications

References 0 publications

Smoking during pregnancy: a significant cause of neonatal thyroid enlargement

Smoking during pregnancy: a significant cause of neonatal thyroid enlargement

Distribution and Variation of Indole Glucosinolates in Woad (Isatis tinctoria L.)

Etiological Factors for the Persistence of Endemic Goiter in Selected Areas of Siddharthnagar District in Eastern Uttar Pradesh, India

Contact Info

Product

Resources

About