Studien über die Untergruppen A1 und A2 mit besonderer Berücksichtigung der Paternitätsuntersuchungen

Wolff, Erik; Jonsson, Bengt R.

doi:10.1007/bf01756867

Cited by 14 publications

(6 citation statements)

References 4 publications

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“…Anti-M is a fairly common naturally occurring antibody[ 1 2 ] originally described by Wolff and Johnsson in 1933. [ 3 ] Only rarely it has been implicated as a cause of immediate and delayed[ 4 – 5 ] hemolytic transfusion reactions or hemolytic disease of the newborn. [ 6 ] Though it is the frequently encountered antibody of the MNSs blood group system, it is not considered to be clinically significant.…”

Section: Introductionmentioning

confidence: 99%

Anti-M: Report of two cases and review of literature

Tondon

Kataria

Chaudhry

2008

Asian J Transfus Sci

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Anti-M is a fairly common naturally occurring antibody with rarely causing hemolytic transfusion reactions or hemolytic disease of the newborn. Most anti-M are not active at 37°C and can generally be ignored in transfusion practice. However, we did not find this antibody to be fairly common and detected only two cases of anti-M in the past three years. We describe these two cases; one ‘immunizing’ type and other ‘naturally occurring’ and review the literature. The immunizing type was reactive at 37°C as well as AHG phase of testing with IgG component, and showing dosage effect while the other was ‘naturally occurring’ reactive well below 37°C. Though rare, sometimes these antibodies can be of clinical significance when the antibody detected is reactive at 37°C and AHG phase. When the antibody is active at 37°C, M antigen negative cross match compatible red cell unit should be given.

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Section: Introductionmentioning

confidence: 99%

Anti-M: Report of two cases and review of literature

Tondon

Kataria

Chaudhry

2008

Asian J Transfus Sci

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“…Anti-M also occurs naturally in individuals whose red blood cells lack the M antigen and have no history of sensitisation 4. Anti-M antibodies are naturally occurring antibodies which were first described by Wolff and Jonsson in 1933 5. They are the most frequently encountered antibodies of the MNS blood group system 6.…”

Section: Discussionmentioning

confidence: 99%

Anti-M antibodies as a cause of intrauterine fetal death and neonatal hyperbilirubinaemia

Sharma

Murki

et al. 2014

BMJ Case Reports

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A preterm male infant (35 weeks), appropriate for gestational age with birth weight of 2.20 kg was born to a 28-year G2 P0 mother. The mother's blood group was A positive and the father's was B positive. Her first pregnancy was an intrauterine fetal death due to immune hydrops. The mother's blood was positive for indirect Coomb's test with 1:32 dilution and anti-M antibodies. This pregnancy was induced at 35 weeks of gestation. Investigations from the cord blood revealed A positive blood group, positive direct Coomb's test, haematocrit of 41.4%, cord reticulocyte count of 5.3% and total serum bilirubin (TSB) of 2.7 mg/dL. Phototherapy was started at 27 h of life for visible jaundice. In view of progressive pallor and a sudden rise of bilirubin, the infant was subjected to exchange transfusion on day 5 of life. The transfusion was given with O negative and anti-M antibodies negative donor blood. Total serum bilirubin (TSB) prior to exchange transfusion was 28 mg/dL and packed cell volume (PCV) was 21%. Phototherapy was continued for a total duration of 8 days.

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“…It was the second blood group system to be recognized following the discovery of ABO blood group system. The anti-M antibody was first discovered by Wolf and Johnson in 1933 [1]. This is a relatively common, naturally occurring antibody, usually of IgM type [2].…”

Section: To the Editormentioning

confidence: 99%

Importance of Clinically Significant Anti-M Antibody in Hematopoietic Stem Cell Transplantation

Datta

Basu

2015

Indian J Hematol Blood Transfus

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Naturally occurring anti-M antibodies are mostly of the IgM class, however, an IgG component can also be present along with IgM. The IgM anti-M antibodies can be ignored if they are not reactive at 37°C, but the patient should receive M antigen-negative red blood cells if the antibody is reactive at 37°C or if it is of IgG class. Here we discuss a case of clinically significant naturally occurring anti-M antibody had both IgM and IgG components in a 3 years old child who was a hematopoietic stem cell donor for her 6 years old sister suffering from betathalassemia major. The specificity and immunoglobulin class of the antibody was confirmed by antibody screening at wide thermal range, dithiothreitol treatment of serum and reaction of serum with enzyme treated panel cells.

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Studien über die Untergruppen A1 und A2 mit besonderer Berücksichtigung der Paternitätsuntersuchungen

Cited by 14 publications

References 4 publications

Anti-M: Report of two cases and review of literature

Anti-M: Report of two cases and review of literature

Anti-M antibodies as a cause of intrauterine fetal death and neonatal hyperbilirubinaemia

Importance of Clinically Significant Anti-M Antibody in Hematopoietic Stem Cell Transplantation

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