Studies About Unconjugated Androstenediol in Human Peripheral Plasma<sup>1</sup>

Demisch, K.; Magnet, W; Neubauer, Manfred; Schöffling, Κ.

doi:10.1210/jcem-37-1-129

Cited by 30 publications

(6 citation statements)

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“…This latter ratio corresponds to that found in the peripheral plasma by Rosenfield and Otto (8) and confirmed by recent studies from two separate laboratories (37,38). After HCG stimulation of similar dosage and duration as performed in our patient, this ratio was either maintained (37) or somewhat increased (38). Furthermore, the ratio was maintained in a variety of testicular disorders before and after HCG stimulation (38).…”

Section: Resultssupporting

confidence: 92%

“…A5-androstene-Schneider, Genel, Bongiovanni, Goldman, and Rosenfield diol is the second most abundant steroid in spermatic vein plasma; the ratio of testosterone to DHA is 37:1, compared to 4: 1 for testosterone to A5-androstenediol (36). This latter ratio corresponds to that found in the peripheral plasma by Rosenfield and Otto (8) and confirmed by recent studies from two separate laboratories (37,38). After HCG stimulation of similar dosage and duration as performed in our patient, this ratio was either maintained (37) or somewhat increased (38).…”

Section: Resultssupporting

confidence: 73%

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Persistent testicular delta5-isomerase-3beta-hydroxysteroid dehydrogenase (delta5-3beta-HSD) deficiency in the delta5-3beta-HSD form of congenital adrenal hyperplasia.

Schneider¹,

Genel²,

Bongiovanni³

et al. 1975

J. Clin. Invest.

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A B S T R A C T A partial testicular defect in testosterone secretion has been documented in a pubertal male with a congenital adrenal hyperplasia due to hereditary deficiency of the A5-isomerase-3fi-hydroxysteroid dehydrogenase enzyme complex (AY-3j-HSD). Diagnosis of the enzymatic defect is based on the clinical picture of ambiguous genitalia and salt-losing crisis in infancy, together with high urinary A5-pregnenetriol and plasma dehydroepiandrosterone when the patient was taken off replacement corticoid treatment. No hormonal response to ACTH or salt deprivation was demonstrable. In addition, in vivo studies revealed a partial enzymatic defect in the testis. Although plasma testosterone was low-normal (250 ng/100 ml), plasma A5-androstenediol was markedly elevated and rose to a greater extent than testosterone after human chorionic gonadotropin administration. In vitro testicular incubation studies suggested a testicular A5-3%-HSD enzyme defect with less A4 products formed from A5 precursors than in a control testis. Histochemical studies of the testis were also consistent with this defect. Testicular biopsy revealed spermatoAn abstract of a portion of this work has appeared in Pediatr. Res.

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Section: Resultssupporting

confidence: 92%

Section: Resultssupporting

confidence: 73%

Persistent testicular delta5-isomerase-3beta-hydroxysteroid dehydrogenase (delta5-3beta-HSD) deficiency in the delta5-3beta-HSD form of congenital adrenal hyperplasia.

Schneider¹,

Genel²,

Bongiovanni³

et al. 1975

J. Clin. Invest.

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“…This means that all of the A 5 -diol in women is derived from secreted DHEA, while approximately 60% is so derived in men. A 5 -Diol has previously been reported (27) as a secretory product of the testes and this source may account for at least part of the other 40%.…”

Section: Discussionmentioning

confidence: 89%

Dehydroepiandrosterone: Kinetics of Metabolism in Normal Men and Women*

Bird

Murphy

Boroomand

et al. 1978

The Journal of Clinical Endocrinology & Metabolism

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The single injection and constant infusion techniques were utilized to study the kinetics of dehydroepiandrosterone (DHEA) metabolism and its peripheral conversion to several other C19-steroids including C19-steroid sulfates. The MCRs (mean +/- SEM) for normal men and normal women were 1866 +/- 144 and 1901 +/- 87 liters/24 h, respectively. The single injection technique yielded values for rate constants (units) and volumes of distribution (1) as follows: K1, 42.6 +/- 7.7 for men and 37.1 +/- 5.0 for women; K2, 64.3 +/- 11.2 for men and 55.5 +/- 5.0 for women; K2, 64.3 +/- 11.2 for men and 55.5 +/- 5.0 for women; V1, 38.5 +/- 6.0 for men and 33.7 +/- 2.5 for women; V2, 30.4 +/- 7.3 for men and 27.5 +/- 9.9 for women. The constant infusion technique yielded values for the conversion ratios for the transformation of DHEA to several products: delta 5-androstene-3 beta, 17 beta-diol to DHEA of 0.10 +/- 0.01 for men and 0.16 +/- 0.03 for women, delta 4-androstenedione to DHEA of 0.04 +/- 0.01 for men and 0.07 +/- 0.02 for women, DHEA sulfate (DHEAS) to DHEA of 6.36 +/- 0.81 for men and 10.09 +/- 0.87 for women, delta 5-androstene-3 beta, 17 beta-diol sulfate to DHEA of 0.42 +/- 0.06 for men and 0.50 +/- 0.04 for women, and androsterone sulfate to DHEA of 1.11 +/- 0.13 for men and 2.06 +/- 0.18 for women. The ratios for the conversion to DHEA sulfate and androsterone sulfate were significantly higher for women than men. The plasma concentrations of DHEA were 8.50 +/- 0.95 and 8.75 +/- 1.01 ng/ml for men and women, respectively. The calculated production rates for DHEA were 16.34 +/- 2.66 and 16.19 +/- 1.78 mg/24 h for men and women, respectively. There was no sex difference in the binding of DHEA to plasma proteins and this is reflected in the lack of sex difference in the MCRs. Calculations indicate that DHEA is a major precursor of circulating delta 5-diol.

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“…Ce diol insaturé est présent dans le plasma à des taux de 1060-1610 pg/ml chez l'homme et de 615-1020 pg/ml chez la femme [11,25] et est connu comme interférent dans les techniques de dosage RIA dépourvues de chromatographie préalable. Le stéroïde 5α androstane-3α,17α diol est un métabolite de la DHT qui n'est observé qu'après administration de DHT par voie orale [27].…”

Section: Prépurification Chromatographique Sur Celiteunclassified

Détermination de la testostérone biodisponible chez la femme adulte par chromatographie en phase gazeuse–spectrométrie de masse avec dilution isotopique (ID-GCMS). Comparaison avec la méthode de routine à la testostérone tritiée

Meunier

Helden

2007

Immuno-analyse & Biologie Spécialisée

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Studies About Unconjugated Androstenediol in Human Peripheral Plasma¹

Cited by 30 publications

References 0 publications

Persistent testicular delta5-isomerase-3beta-hydroxysteroid dehydrogenase (delta5-3beta-HSD) deficiency in the delta5-3beta-HSD form of congenital adrenal hyperplasia.

Persistent testicular delta5-isomerase-3beta-hydroxysteroid dehydrogenase (delta5-3beta-HSD) deficiency in the delta5-3beta-HSD form of congenital adrenal hyperplasia.

Dehydroepiandrosterone: Kinetics of Metabolism in Normal Men and Women*

Détermination de la testostérone biodisponible chez la femme adulte par chromatographie en phase gazeuse–spectrométrie de masse avec dilution isotopique (ID-GCMS). Comparaison avec la méthode de routine à la testostérone tritiée

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Studies About Unconjugated Androstenediol in Human Peripheral Plasma1

Cited by 30 publications

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Persistent testicular delta5-isomerase-3beta-hydroxysteroid dehydrogenase (delta5-3beta-HSD) deficiency in the delta5-3beta-HSD form of congenital adrenal hyperplasia.

Persistent testicular delta5-isomerase-3beta-hydroxysteroid dehydrogenase (delta5-3beta-HSD) deficiency in the delta5-3beta-HSD form of congenital adrenal hyperplasia.

Dehydroepiandrosterone: Kinetics of Metabolism in Normal Men and Women*

Détermination de la testostérone biodisponible chez la femme adulte par chromatographie en phase gazeuse–spectrométrie de masse avec dilution isotopique (ID-GCMS). Comparaison avec la méthode de routine à la testostérone tritiée

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Studies About Unconjugated Androstenediol in Human Peripheral Plasma¹