Studies in burns. XI. Ethyl linoleate: the waterholding lipid of skin. B. Effects on in vivo burn eschar

Jelenko, Carl; Wheeler, M L; Scott, Thomas H.

doi:10.1097/00006534-197308000-00058

Cited by 2 publications

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“…Linoleic acid also plays an indisputable role, not only in the essential fatty acid-deficient rat, but also in other unrelated instances of impaired cutaneous barrier function. Jelenko, Wheeler & Scott (1972) showed that application of ethyl linoleate to experimentally burned rabbit skin caused a marked reduction ofthe elevated rate of transepidermal water loss, and Prottey et al (1976) have shown that linoleic acid, topically applied as sunfiower seed oil, rapidly lowers elevated water loss through the skin of rats exaggeratedly washed with detergent.…”

Section: Speculative Roles Of Essential Fatty Acids In Skinmentioning

confidence: 99%

Essential Fatty Acids and the Skin

Prottey

1976

Br J Dermatol

125

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Section: Speculative Roles Of Essential Fatty Acids In Skinmentioning

confidence: 99%

Essential Fatty Acids and the Skin

Prottey

1976

Br J Dermatol

125

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“…Furthermore, there are data which suggest that linoleic acid is important in the repair of cutaneous barrier function. For example, Jelenko, Wheeler and Scott (1972) showed that with experimentally burned rabbit skin, application of ethyl linoleate lowered the elevated rate of skin water loss, and Prottey et al (1976) have shown that following excessive application of detergent to the skin of rats, the raised TEWL that accompanied the irritation response was rapidly reduced by application of sunflower seed oil. Here we have examined the hypothesis that cutaneous application of linoleic acid (as sunflower seed oil), may be important in the repair of barrier function and in skin healing in psoriasis.…”

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confidence: 99%

Comparison of barrier function and lipids in psoriasis and essential fatty acid-deficient rats

1978

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Summary Elevated rates of transepidermal water loss (TEWL) in plaques of human psoriasis and in the skin of essential fatty acid (EFA)‐deficient rats were compared. Cutaneous application of sunflower seed oil to EFA‐deficient rats lowered the rate of TEWL to normal, healed the characteristic scaly skin of this condition and increased the incorporation of linoleic acid of the sunflower seed oil into epidermal phospholipid. Application of sunflower seed oil to psoriatic skin did not lower the TEWL, nor produce clinical improvement, but the linoleic acid of epidermal phospholipid was increased. Local application of a steroid ointment, clobetasol propionate (Dermovate) reduced the elevated TEWL in psoriasis and produced clinical improvement, but had no effect upon skin or plasma lipids. Application of this steroid to EFA‐deficient rat skin cleared the skin scaliness but did not restore barrier function or change the composition of the skin lipids. It is concluded that the impaired barrier function in psoriasis is not due to EFA‐deficiency.

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Studies in burns. XI. Ethyl linoleate: the waterholding lipid of skin. B. Effects on in vivo burn eschar

Cited by 2 publications

References 0 publications

Essential Fatty Acids and the Skin

Essential Fatty Acids and the Skin

Comparison of barrier function and lipids in psoriasis and essential fatty acid-deficient rats

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