Studies in calcium and magnesium metabolism. Further observations on the effect of acid and dietary factors

Givens, Maurice H.

doi:10.3181/00379727-15-147

Cited by 11 publications

(12 citation statements)

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“…34,35 Nevertheless, intakes of whole grain, 36 nuts, 37 and fruits and vegetables, 38 which are the major foods contributing to magnesium intake, have been shown to be inversely related to body weight. The relation between magnesium and blood pressure has been studied for decades.…”

Section: He Et Al Magnesium and Metabolic Syndromementioning

confidence: 99%

Magnesium Intake and Incidence of Metabolic Syndrome Among Young Adults

et al. 2006

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Background-Studies suggest that magnesium intake may be inversely related to risk of hypertension and type 2 diabetes mellitus and that higher intake of magnesium may decrease blood triglycerides and increase high-density lipoprotein (HDL) cholesterol levels. However, the longitudinal association of magnesium intake and incidence of metabolic syndrome has not been investigated. Methods and Results-We prospectively examined the relations between magnesium intake and incident metabolic syndrome and its components among 4637 Americans, aged 18 to 30 years, who were free from metabolic syndrome and diabetes at baseline. Metabolic syndrome was diagnosed according to the National Cholesterol Education Program/Adult Treatment Panel III definition. Diet was assessed by an interviewer-administered quantitative food frequency questionnaire, and magnesium intake was derived from the nutrient database developed by the Minnesota Nutrition Coordinating Center. During the 15 years of follow-up, 608 incident cases of the metabolic syndrome were identified. Magnesium intake was inversely associated with incidence of metabolic syndrome after adjustment for major lifestyle and dietary variables and baseline status of each component of the metabolic syndrome. Compared with those in the lowest quartile of magnesium intake, multivariable-adjusted hazard ratio of metabolic syndrome for participants in the highest quartile was 0.69 (95% confidence interval [CI], 0.52 to 0.91; P for trend Ͻ0.01). The inverse associations were not materially modified by gender and race. Magnesium intake was also inversely related to individual component of the metabolic syndrome and fasting insulin levels. Conclusions-Our findings suggest that young adults with higher magnesium intake have lower risk of development of metabolic syndrome.

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Section: He Et Al Magnesium and Metabolic Syndromementioning

confidence: 99%

Magnesium Intake and Incidence of Metabolic Syndrome Among Young Adults

et al. 2006

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“…The experiments of Givens and Mendel (3) and of Givens (4) upon the effect of base and acid on the general metabolism tended to minimize variations in calcium excretion resulting from this factor. Subsequently, Goto (5), using rabbits, demonstrated depletion of the skeleton by repeated doses of hydrochloric acid.…”

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confidence: 99%

Studies of Calcium and Phosphorus Metabolism

Farquharson¹,

Salter²,

Tibbetts³

et al. 1931

J. Clin. Invest.

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In the course of our studies in calciulm metabolism evidence has steadily accumulated that the metabolism of acid-producing substances plays an important r6le in influencing the assimilation and excretion of calcium. This effect, however, has not been adequately studied in man, and in other studies of calcium exchange the potential acidity or alkalinity of foods and medication has largely been neglected.It is the purpose of the present investigation to follow the effect of food-stuffs and inorganic salts on calcium metabolism with relation to their potential acidity (after oxidation) referred to the hydrogen ion concentration of the blood.Studies in rickets for some time have indicated the importance of acidity to the assimilation and storage of inorganic salts in bone. Thus, McClendon (1) noted that the addition of alkali to a diet increased its power to produce rickets and, conversely, Zucker, Johnson, and Barnett (2) reported that the change in acidity of diets from the alkaline toward the acid side of neutrality might result in healing of the rachitic lesions.Much work, too, has been done upon the effect of administered acid on the mineral excretion. The experiments of Givens and Mendel (3) and of Givens (4) upon the effect of base and acid on the general metabolism tended to minimize variations in calcium excretion resulting from this factor. Subsequently, Goto (5), using rabbits, demonstrated depletion of the skeleton by repeated doses of hydrochloric acid. Lamb and Evvard (6) demonstrated increased urinary calcium

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“…This, we appreciate, is no explanation of how 1 Givens (8) and Givens and Mendel (9) likewise found no increase in fecal calcium in dogs as a result of acidosis although Stehle (1O).found a very definite increase.…”

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confidence: 91%