Studies in Diseases of Muscle, Viii

The Pharmacology of Sodium Hydroxyacetate with Observations on the Toxicity of Glycine*†

“…The behavior of hydroxyacetic acid (glycolic acid) in the animal organism has received some consideration in the literature (1,2,3,4). Concerning the questions of whether glycolic acid is a normal product of intermediary metabolism, whether the animal organism can produce it under any conditions, and the behavior of injected material, the existing evidence is inconclusive.…”

“…Metabolism of Hydroxyacetic Acid--It has been shown in several studies (1,2) that the conversion of hydroxyacetic acid into oxalic acid which takes place in vitro does not occur in animals or man.…”