Studies in experimental endotoxemia in man

Ollodart, Robert; Hawthorne, Ilse; Attar, Safuh

doi:10.1016/0002-9610(67)90305-4

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Effect Of Endotoxin1

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2007

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Cited by 12 publications

(1 citation statement)

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“…23 Afterwards, the metabolic and endocrine effects of endotoxin were described24·25 and the intravenous injection of endotoxin became a widely used experimental model. 26 ln the present study 2 ng/kg was injected, as doses 2--4 ng/kg of LPS have been given to healthy humans on several occasions by other investigators, without any major adverse effect.…”

Section: Effect Of Endotoxinmentioning

confidence: 99%

Effects of fish oil on the neuro-endocrine responses to an endotoxin challenge in healthy volunteers

et al. 2007

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Section: Effect Of Endotoxinmentioning

confidence: 99%

Effects of fish oil on the neuro-endocrine responses to an endotoxin challenge in healthy volunteers

et al. 2007

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In Vivo Effect of Polymyxin B on Pertussis Vaccine

Larter¹

1984

Arch Pediatr Adolesc Med

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Sinusoidal circulatory disturbance by microthrombosis as a cause of endotoxin‐induced hepatic injury

Shibayama

1987

The Journal of Pathology

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The present study was undertaken in rats to examine the significance of sinusoidal circulatory disturbance by microthrombosis in the pathogenesis of hepatic damage and dysfunction due to endotoxin. Administration of endotoxin induced fibrin deposits and infiltration of polymorphonuclear leukocytes in the sinusoids, focal random coagulative hepatocellular necrosis and elevation of serum transaminase activities. When heparin was given simultaneously with endotoxin, the formation of fibrin thrombus in the sinusoids was prevented, and the endotoxin-induced morphological and functional changes in the liver were markedly inhibited. Infusion of thrombin into the portal vein induced a large amount of fibrin thrombi in the sinusoids, focal random necrotic foci resembling the lesions produced by endotoxin and elevation of levels of serum transaminases. These experimental data suggest that disturbance of hepatic microcirculation by sinusoidal thrombosis is the necessary and sufficient condition for the development of endotoxin-induced hepatic injury.

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Studies in experimental endotoxemia in man

Cited by 12 publications

References 10 publications

Effects of fish oil on the neuro-endocrine responses to an endotoxin challenge in healthy volunteers

Effects of fish oil on the neuro-endocrine responses to an endotoxin challenge in healthy volunteers

In Vivo Effect of Polymyxin B on Pertussis Vaccine

Sinusoidal circulatory disturbance by microthrombosis as a cause of endotoxin‐induced hepatic injury

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