Studies in hypertension

Eg, Clark; Cy, Glock; Schweitzer,; Rl, Vought

doi:10.1016/0021-9681(56)90067-4

Cited by 11 publications

(2 citation statements)

References 2 publications

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“…The risk of multiple myeloma is significantly increased in individuals with low-SES 11–13 , however, the impact of SES on MM prognosis is unclear. Some studies have observed poorer survival among patients in lower-SES groups 14–17 , while others have not 18–20 .…”

Section: Introductionmentioning

confidence: 99%

Socioeconomic status is independently associated with overall survival in patients with multiple myeloma

Fiala

Finney

Liu

et al. 2015

Leukemia & Lymphoma

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Population-based studies suggest that black patients with multiple myeloma (MM) have a higher mortality rate than white patients; however, other studies suggest this disparity is related to socioeconomic status (SES) rather than race. To provide clarity on this topic, we reviewed 562 patients diagnosed with MM at our institution. Patients with high-SES had a median OS of 62.8 months (mos) (95% CI 43.1–82.6 mos), compared to 53.7 mos (45.2–62.3 mos) and 48.6 mos (40.4–56.8 mos) for the middle and low-SES, respectively (p =0.015). After controlling for race, age, year of diagnosis, severity of comorbidities, stem cell transplant utilization, and insurance provider, patients with low-SES had a 54 percent increase in mortality rate relative to patients with high-SES. To support our findings, we performed a similar analysis of 45,505 patients with MM from the Surveillance Epidemiology and End Results-18 (SEER) database. Low-SES is independently associated with poorer OS in MM.

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Section: Introductionmentioning

confidence: 99%

Socioeconomic status is independently associated with overall survival in patients with multiple myeloma

Fiala

Finney

Liu

et al. 2015

Leukemia & Lymphoma

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“…The intraindividual fluctuation of BP is physiologically attributed to baroreflex, autonomic function, and response to challenge. 15,16 Several streams of evidence suggest that short-term BPV (eg, beat-to-beat and within 24 hours) is independently associated with end-organ damage and cardiovascular events. [17][18][19] However, the implications of long-term BPV (eg, day-by-day and visit-to-visit BPV) are less defined, particularly as it may affect kidney function.…”

mentioning

confidence: 99%

Associations of Long-Term Visit-to-Visit Blood Pressure Variability With Subclinical Kidney Damage and Albuminuria in Adulthood: a 30-Year Prospective Cohort Study

Wang

Zhao

Chu³

et al. 2022

Hypertension

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Background: Recent evidence indicates that long-term visit-to-visit blood pressure variability (BPV) may be associated with risk of cardiovascular disease. We, therefore, aimed to determine the potential associations of long-term BPV from childhood to middle age with subclinical kidney damage (SKD) and albuminuria in adulthood. Methods: Using data from the ongoing cohort of Hanzhong Adolescent Hypertension study, which recruited children and adolescents aged 6 to 18 years at baseline, we assessed BPV by SD and average real variability (ARV) for 30 years (6 visits). Presence of SKD was defined as estimated glomerular filtration rate between 30 and 60 mL/min per 1.73 m 2 or elevated urinary albumin-to creatinine ratio at least 30 mg/g. Albuminuria was defined as urinary albumin-to creatinine ratio ≥30 mg/g. Results: During 30 years of follow-up, of the 1771 participants, 204 SKD events occurred. After adjustment for demographic, clinical characteristics, and mean BP during 30 years, higher SD SBP , ARV SBP , SD DBP , ARV DBP , SD MAP , ARV MAP , and ARV PP were significantly associated with higher risk of SKD. When we used cumulative exposure to BP from childhood to adulthood instead of mean BP as adjustment factors, results were similar. In addition, greater long-term BPV was also associated with the risk of albuminuria. Long-term BPV from childhood to middle age was associated with higher risk of SKD and albuminuria in adulthood, independent of mean BP or cumulative exposure to BP during follow-up. Conclusions: Identifying long-term BPV from early age may assist in predicting kidney disease and cardiovascular disease in later life.

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