Studies in Iron Metabolism With the Aid of Its Artificial Radioactive Isotope

Ferritin: Its Properties and Significance for Iron Metabolism.

“…Recent studies have brought to light a number of interesting facts which govern the process of iron absorption. The iron is apparently absorbed in the ferrous state (23,27,28,35,52,56), various portions of the gastrointestinal tract being capable of absorbing it (3,7,20).…”

Radioactive Isotopes as Indicators in Biology.

“…Some details have been added by further study, but the essential results have been fully confirmed by subsequent experiments. For example, Austoni and Greenberg (12) found that relatively more iron is absorbed by normal rats than Hahn et al noted in normal dogs. They also observed greater differences in absorption of iron between normal and anemic rats than had been found in dogs.…”

“…However, even if this indicated direct reversal of the reaction should be established, and the series of reactions given below should therefore require considerable modification, it would still be necessary to postulate the formation and decarboxylation of dicarboxylic acids in order to account for the experimental results obtained by Hastings and his coworkers. \ (12) opo3h2…”

“…The initial fixation of inorganic iodide by the thyroid is followed by fairly rapid conversion to organic forms. Lein (173) found more organically bound iodine present in the gland 12 hr. after the administration of the tracer than had been initially fixed as iodide.…”