1939
DOI: 10.1172/jci101069
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Studies in Iron Transportation and Metabolism. Iv. Observations on the Absorption of Iron From the Gastro-Intestinal Tract 12

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1939
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Cited by 95 publications
(23 citation statements)
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“…The difference between the mean absorption with normal gastric juice in this group of six patients with achylia gastrica and the absorption of bread iron alone in control subjects was not statistically significant. food (1-3, 7, 15, 16) but plays no part in the absorption of larger doses of inorganic iron salts (8)(9)(10)(11) or of hemoglobin iron (12,13). The only work at variance with the postulate that gastric secretion plays a role in the absorption of food iron is the study of Pirzio-Biroli, Bothwell, and Finch (14), who observed that four subjects with achylia gastrica and a larger group of control subjects both absorbed 5.3% of iron from a standard meal.…”
Section: Methodsmentioning
confidence: 99%
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“…The difference between the mean absorption with normal gastric juice in this group of six patients with achylia gastrica and the absorption of bread iron alone in control subjects was not statistically significant. food (1-3, 7, 15, 16) but plays no part in the absorption of larger doses of inorganic iron salts (8)(9)(10)(11) or of hemoglobin iron (12,13). The only work at variance with the postulate that gastric secretion plays a role in the absorption of food iron is the study of Pirzio-Biroli, Bothwell, and Finch (14), who observed that four subjects with achylia gastrica and a larger group of control subjects both absorbed 5.3% of iron from a standard meal.…”
Section: Methodsmentioning
confidence: 99%
“…Early clinical studies in which iron absorption was measured by the rate of hemoglobin regeneration in iron-deficient subjects suggested that gastric acidity plays a role in the absorption of food iron (1-3), therapeutic doses of inorganic iron salts, and ferrum reductum (4)(5)(6). Defective absorption of dietary iron has been demonstrated in achlorhydric subjects by a chemical balance technique (7), but several workers using serum iron tolerance curves as an index of absorption have reported that achlorhydria does not reduce the assimilation of large doses of inorganic iron salts (8)(9)(10). More recent data obtained by isotopic methods are conflicting, and in many instances the number of observations is too few to support firm conclusions.…”
mentioning
confidence: 99%
“…It is well recognized that patients with iron deficiency anemia absorb iron at an accelerated rate (40 to 42) but the increase in plasma iron following its ingestion may be insignificant or quite pronounced (40). In the case of iron deficiency anemia in which the studies illustrated in Figures 5 and 6 Figure 1).…”
Section: Chemical Studiesmentioning
confidence: 99%
“…The subject has been reviewed by a number of investigators (12,14,17,18). Changes in plasma iron as an index of absorption have been studied by these workers.…”
Section: Plasma and Serum Ironmentioning
confidence: 99%