Studies in Pancreatic Function

ESPGHAN and NASPGHAN Report on the Assessment of Exocrine Pancreatic Function and Pancreatitis in Children

“…Although little used, the pancreatic stimulation test (Dreiling tube test) is considered the criterion standard for the assessment of exocrine pancreatic function (56). Figure 3(57) provides a schematic of the procedure.…”

Duodenal Intubation in Diagnosis

“…The bicarbonate response shows a wide variation among normal individuals, and in any one case the functional reserve of the pancreas is great; however, a maximum value of So milliequivalents per litre has been taken as the lowest limit of normal, in accordance with the observations of Dreiling and Hollander (1950).…”

“…A Type IV has been described by Dreiling (1950) with a response, intermediate between Type I and Type II, in which, after cholecystectomy, the common bile duct is dilated and appears to act as a biliary reservoir, associated with incomplete biliary obstruction, either by residual stone or by stenosis. Snape et alii (1948) have shown that there is a high degree of correlation between the ordinary Graham's test and the secretin test of biliary function both in normal and abnormal conditions of the biliary tract, but suggest that the secretin test has little general application by virtue of its being more cumbersome than oral cholecystography.…”

“…Duodenal intubation, however, may in some instances give valuable information, without resort to a second laparotomy. Dreiling (1950) reviewed his findings with duodenal intubation and the secretin test in ninety-eight such patients, in an attempt to find the incidence of chronic pancreatic disease.…”

An Endoscopic Method for the Study of the Exocrine Pancreatic Secretion in Man

“…Previously, exocrine pancreatic secretion has been studied in duodenal aspirates obtained before and after exogenous stimulants (1,2,4,6) or test meals (3). Recently, duodenoscopy with cannulation of the main pancreatic duct has been used for collection of pancreatic juice after stimulation with gastrointestinal hormones (5).…”