Studies in Renal Circulation During Periods of Life Stress and Accompanying Emotional Reactions in Subjects With and Without Essential Hypertension; Observations on the Role of Neural Activity in Regulation of Renal Blood Flow 1

Pfeiffer, John B.; Wolff, Harold G.; Winter, Oliver S.

doi:10.1172/jci102361

Cited by 48 publications

(13 citation statements)

References 18 publications

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“…This is of interest in comparison with the data of Pfeiffer and Wolff (32) which indicated that the functional response of the kidney to pressor influences was altered similarly by sympathectomy. SUMMARY 1.…”

Section: Discussionmentioning

confidence: 73%

Clinical Studies on Veratrum Alkaloids. Iii. The Effect of Protoveratrine on Renal Function in Man 1

Meilman¹

1953

J. Clin. Invest.

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Section: Discussionmentioning

confidence: 73%

Clinical Studies on Veratrum Alkaloids. Iii. The Effect of Protoveratrine on Renal Function in Man 1

Meilman¹

1953

J. Clin. Invest.

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“…It is well documented that mental stress elicits renal vasoconstriction (13,15,21,23,33), yet the influence of exercise training on renal vasoconstriction during mental stress has not been previously examined in humans. However, aerobic exercise training has been shown to blunt the reduction of renal blood flow during psychological stress in borderline hypertensive rats (19).…”

Section: Discussionmentioning

confidence: 99%

“…In addition to eliciting sympathoexcitation, mental stress consistently causes renal vasoconstriction in humans (13,15,21,23,33). Elevated renal vascular resistance has been associated with essential hypertension (28); thus it is important to study interventions that may blunt the reduction of renal vasoconstriction during mental stress.…”

mentioning

confidence: 99%

Effects of aerobic exercise training on sympathetic and renal responses to mental stress in humans

Ray

Carter

2010

American Journal of Physiology-Heart and Circulatory Physiology

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Ray CA, Carter JR. Effects of aerobic exercise training on sympathetic and renal responses to mental stress in humans. Am J Physiol Heart Circ Physiol 298: H229 -H234, 2010. First published November 13, 2009; doi:10.1152/ajpheart.00880.2009.-The effects of aerobic exercise training (ET) on muscle sympathetic nerve activity (MSNA) and renal vascular responses to mental stress (MS) have not been determined in humans. We hypothesized that aerobic ET would reduce MSNA and renal vasoconstriction during MS. MSNA, mean arterial pressure (MAP), heart rate, renal blood flow velocity (RBFV), and peak oxygen uptake (V O2 peak) were recorded in 23 healthy adults. Fourteen subjects participated in 8 wk of aerobic ET, while nine subjects served as sedentary controls (Con). ET significantly increased V O2 peak (⌬18 Ϯ 1%; P Ͻ 0.001) and decreased RBFV at rest (60 Ϯ 4 to 48 Ϯ 3 cm/s; P Ͻ 0.01), whereas Con did not alter V O2 peak or RBFV. ET did not alter resting MSNA (11 Ϯ 1 to 9 Ϯ 1 bursts/min) or MAP (84 Ϯ 2 to 83 Ϯ 2 mmHg), and these findings were similar in the Con group. MS elicited similar increases in MSNA (ϳ⌬2 bursts/min; P Ͻ 0.05), MAP (ϳ⌬15 mmHg; P Ͻ 0.001), and heart rate (ϳ⌬20 beats/min; P Ͻ 0.001) before and after ET, and the responses were not different between ET and Con. Likewise, MS elicited similar decreases in RBFV and renal vascular conductance before and after ET, and the responses were not different between ET and Con. Perceived stress levels during MS were similar before and after the 8-wk study in both ET and Con. In conclusion, ET does not alter MSNA and renal vascular responses to MS in healthy humans.

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“…Using personal interview techniques to create life stress and emotional reactions, it was observed that the increases in mean arterial pressure, decreases in renal plasma flow, and increases in renal vascular resistance were greater in hypertensive than in normotensive human subjects (41,49). Glomerular filtration was unaffected and, therefore, filtration fraction increased.…”

Section: Studies In Human Subjectsmentioning

confidence: 99%

Interaction of Stress and Dietary NaCl Intake in Hypertension: Renal Neural Mechanisms

DiBona

2013

Comprehensive Physiology

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A synthesizing concept of the development of primary hypertension is that it arises from an interaction of genetic and environmental factors. Of the environmental factors, dietary NaCl intake and mental stress are among the most thoroughly investigated. This review will focus on the interaction between genetic predisposition and the environmental influences of dietary NaCl intake and mental stress in the development of primary hypertension.

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Studies in Renal Circulation During Periods of Life Stress and Accompanying Emotional Reactions in Subjects With and Without Essential Hypertension; Observations on the Role of Neural Activity in Regulation of Renal Blood Flow 1

Cited by 48 publications

References 18 publications

Clinical Studies on Veratrum Alkaloids. Iii. The Effect of Protoveratrine on Renal Function in Man 1

Clinical Studies on Veratrum Alkaloids. Iii. The Effect of Protoveratrine on Renal Function in Man 1

Effects of aerobic exercise training on sympathetic and renal responses to mental stress in humans

Interaction of Stress and Dietary NaCl Intake in Hypertension: Renal Neural Mechanisms

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