Studies in the biochemistry of micro-organisms

Abstract

IN a recent communication [Raistrick & Smith, 1936] it was shown that a strain of Aspergillus terreus Thom, when grown on Czapek-Dox solution containing KCI asthe sole source of chlorine, produced two new mould metabolic products, geodin, C17H1207C12, i.e. C,5H605C12(OCH3)2, and erdin, C16HI007Cf2, i.e. C15H706C12(OCH3),

(+)-Geodin fromAspergillus terreus

“…(+)-Geodin, (I), was originally isolated from Aspergillus terreus (Raistrick & Smith, 1936) and elucidation of its structure was initiated (Clutterbuck et al, 1937;Calam et al, 1939Calam et al, , 1947, eventually resulting in the correct relative structure (Barton & Scott, 1958). A number of biological activities have been reported for (I), including antiviral (Takatsuki, Suzuki et al, 1969;Takatsuki, Yamaguchi et al, 1969), antimicrobial (Rinderknecht et al, 1947), enhancement of fibrinolytic activity (Shinohara et al, 2000) and stimulation of glucose uptake for rat adipocytes (Sato et al, 2005).…”