Studies in the rearrangement reactions involving camphorquinone

Abstract

We described an unprecedented skeletal rearrangement of camphorquinone motif to an interesting tricyclic ring system.Peripheral functional group modification provided a terpene-triazole conjugate.

Synthesis and Antitumor Activity of 1-Substituted 1,2,3-Triazole-Mollugin Derivatives

“…In this manuscript, the key intermediate was obtained by proparylation of the hydroxyl group (C-1) of mollugin ( Figure 1 ). Then a series of mollugin derivatives were synthesized through the click chemistry approach by introducing different substituted aromatic azides [ 22 , 23 , 24 ]. Further the synthesized derivatives were screened for cytotoxicity against five different human cancer cell lines (HL-60, A549, SMMC-7721, SW480, and MCF-7).…”