Studies in the usnic acid series. IV. The base catalyzed usnic acid – isousnic acid rearrangement. Part II. An improved synthesis of (+)-isousnic acid

Kutney, James P.; Sánchez, I. H.; Yee, Trevor

doi:10.1139/v77-149

Cited by 7 publications

(2 citation statements)

References 3 publications

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“…6) was identified as (+) usnic acid. The identity of this compound was confirmed by comparing its spectral data with reported values [14][15][16][17][18][19][20] . Candidiasis and cryptococcosis are opportunistic fungal infections caused by Candida species and Cryptococcus species.…”

Section: Compound Fmentioning

confidence: 60%

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In vitro antifungal activity and phytochemical analysis of lichen Parmelia perlata (L.) Ach.

Singh¹,

Singh²

2020

Int. J. Pharmacognosy Life Sci.

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Fungal diseases like candidiasis and cryptococcosis are the commonest opportunistic infections. Since the difficulties associated with the management of antifungal infections, there is an urgent need for the development of new and effective antifungal agents. In this perspective, natural products are a viable alternative source. The lichen Parmelia perlata, commonly known as stone flower, is traditionally used in the Indian system of medicine. The aim of the present study was to evaluate in vitro antifungal activity of petroleum ether extract of Parmelia perlata against Candida albicans, Candida glabrata, Candida krusei, Candida tropicalis, and Cryptococcus neoformans and its phytochemical analysis. The anti-fungal activity of the extract of Parmelia perlata was determined by measuring the Minimal Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) by microbroth dilution method as per the CLSI (NCCLS M27-A2) guidelines. The extract of Parmelia perlata showed the MIC and MFC against Candida species between 600±28µg/ml to 690±16µg/ml and between 750±90µg/ml to 820±45µg/ml, respectively. In addition, the respective values against Cryptococcus neoformans were 550±17µg/ml and 690±34µg/ml, respectively. Further, Parmelia perlata has yielded an acid named-(+)-6-deacetyl-9b-carbmethoxy-9b-dimethylusnic acid and, a quinine named -6-acetyl-11-carbmethoxy-1,4,7,10-tetrahydroxy-2,8-dimethyl naphthacene-5,12-quinone, which were identified on the basis of spectroscopic studies as 2-acetyl-9b-carbmethoxy-7,9-dihydroxy-8-methyl-1,3(2H,9bH)-dibenzofurandione and naphthacene-5,12-quinone derivative, along with four well known compounds-tridecyl myristate, 3-ketooleanane, arachidyl alcohol and (+) usnic acid, respectively. The results of this study showed that Parmelia perlata is a promising antifungal agent.

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Section: Compound Fmentioning

confidence: 60%

“…On the basis of above observation, compound A (Fig. 1) was identified as (+)-6-diacetyl-9bcarbmethoxy-9b-dimethyl-usnic acid (2-acetyl-9bcarbmethoxy-7,9-dihydroxy-8-methyl-1,3 (2H,9bH)dibenzofurandione) [17][18][19][20] .…”

Section: Compound Amentioning

confidence: 98%