Studies Into the Transplantation Biology of Ultraviolet Light-Induced Tumors

Daynes, Raymond A.; Spellman, Craig W.; Woodward, Jerold G.; Stewart, Dennis A.

doi:10.1097/00007890-197704000-00008

Cited by 67 publications

(27 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The induction and propagation of the tumour has been well characterised elsewhere [8]. When transplanted into normal syngeneic mice, this tumour is usually rejected, but grows progressively in immunosuppressed or UV-treated hosts [9]. Tumour fragments (1 mm 3) were transplanted subcutaneously by trocar into the ventral side of the mice.…”

Section: Implanting Tumoursmentioning

confidence: 99%

Immune responses of diabetic animals

et al. 1979

View full text Add to dashboard Cite

Section: Implanting Tumoursmentioning

confidence: 99%

Immune responses of diabetic animals

et al. 1979

View full text Add to dashboard Cite

“…UV-irradiated mice are unable to reject UV-induced tumors that are highly antigenic and that are rejected by normal syngeneic recipients. Recent work suggests that the lack of tumor rejection is due to the presence of suppressor T lymphocytes (TJ) in the lymphoid organs of UV-irradiated mice (4)(5)(6). The origin of T, and their relationship to UV irradiation is incompletely understood.…”

mentioning

confidence: 99%

Impairment of antigen-presenting cell function by ultraviolet radiation.

Greene

Kripke

et al. 1979

Proc. Natl. Acad. Sci. U.S.A.

231

View full text Add to dashboard Cite

UV light irradiation of BALB/c mice was found to result in impairment of antigen-presenting cell function. Adherent trinitrophenyl-derivatized cells from the peritoneal exudate cell population or the spleen of UV-treated donors could not induce hapten-specific delayed hypersensitivity responses in UV-irradiated syngeneic mice, whereas adherent trinitrophenyl-derivatized cel1s from normal mice were able to do so. The failure to induce immunity in UV-treated mice by utilizing UV-treated adherent antigen-presenting cells was associated with the development of antigen-specific supgressor T cells. The implication of these results for UV-inducescarcinogenesis is discussed.UV light irradiation plays an immunologic role in the induction of certain murine fibrosarcomas and squamous carcinomas (1-3) in addition to its carcinogenic action. UV-irradiated mice are unable to reject UV-induced tumors that are highly antigenic and that are rejected by normal syngeneic recipients. Recent work suggests that the lack of tumor rejection is due to the presence of suppressor T lymphocytes (TJ) in the lymphoid organs of UV-irradiated mice (4-6). The origin of T, and their relationship to UV irradiation is incompletely understood. However, a recent suggestion that processing of antigen is deficient early in the course of UV irradiation (4) raised the possibility that T, induction might result from a defect in the afferent limb of the immune response. To resolve this issue, we have evaluated the effects of UV irradiation on cellular immunity to hapten conjugates of syngeneic cells and have investigated the mechanism of this process.There is substantial evidence that antigen-presenting cells (APCs) participate critically in the generation of immune responses (7). Indeed, the APC has been proposed as the site of expression of immune response (Ir) genes in some antigenic systems (8)(9)(10). Other studies have revealed that H-2 genetic identity between the antigen-coupled APC and the recipient is required for maximal induction (11, 12) and transfer of T cell-dependent delayed type hypersensitivity (DTH) responses. Moreover, similar genetic identity at the I region of H-2 between APC and T helper cells is required for maximal priming effects (13)(14)(15).Previous work has shown that UV irradiation of guinea pig skin rendered it unreactive to topical immunizing doses of dinitrochlorobenzene (16). Moreover, UV irradiation of a skin test site in a human subject markedly decreased the development of the local DTH reaction (17). Furthermore, recent studies in which lymphoid cells were exposed to UV irradiation in vitro (18)(19)(20) demonstrated that UV treatment rendered them incapable of serving as allogeneic stimulators in a mixed leukocyte reaction despite the fact that the H-2 encoded antigens on such cells were not discernibly affected or diminished. Still more recently, human lymphoid cells exposed to UV irradiation in vitro were reported not to efficiently stimulate or present hapten to antigen-reactive cells in an in vitro prolif...

show abstract

“…In the mid-1970s, tumor induction and transplantation experiments by Kripke [36] and Daynes et al [37] provided the basis for subsequent studies into the immunobiology of UVR carcinogenesis. These observations also stimulated a general research interest in identifying the mechanisms of UVR-induced immune supression [18], It is now apparent that the direct and indirect effects of UVR on the compartmentalized circuits of the skin-associated lymphoid tissues re sults in an immunologic milieu that favors suppressorigenic responses to antigens that are encountered within the skin [20,21,38,39],…”

Section: The Experimental Uvr Tumor Modelmentioning

confidence: 99%

“…Unlike most chemically induced skin tu mors [12,13,20], the majority of UVRinduced tumors are immunologically re jected when implanted into normal syn geneic animals [36,37,40]. These so-called UVR regressor tumors are capable of pro gressive growth, however, when transplanted into immunologically compromised hosts, e.g.…”

Section: Immunogenicity O F Uvr-lnduced Murine Skin Tumorsmentioning

confidence: 99%