Studies of a Human Neuron-Like Cell Line in Stroke and Spinal Cord Injury

Reier, Paul J.; Trojanowski, John Q.; Lee, Virginia M.‐Y.; Velardo, Margaret J.

doi:10.1007/978-1-59259-423-8_18

Cited by 1 publication

(2 citation statements)

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“…Following binding, RIG‐I moves to the mitochondria or the membranes associated with the endoplasmic reticulum, where it interacts with an innate immune adaptor protein, MAVS 57,58 . While the localization patterns of many immune proteins have been extensively studied in non‐CNS cell types, similar observations have been made in mouse CNS models or human neuron‐like cell lines 59 . In both mouse brain sections and the neuroblastoma cell line N2a, RIG‐I predominantly localises in the cytoplasm.…”

Section: Immunomodulatory Strategiesmentioning

confidence: 87%

“…57,58 While the localization patterns of many immune proteins have been extensively studied in non-CNS cell types, similar observations have been made in mouse CNS models or human neuron-like cell lines. 59 In both mouse brain sections and the neuroblastoma cell line N2a, RIG-I predominantly localises in the cytoplasm. Another pattern recognition receptor, TLR3, typically resides within endosomal compartments and responds to specific stimuli such as poly.…”

Section: Immune-proteins Of Hostmentioning

confidence: 99%

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Modulation of immune responses in the central nervous system by Zika virus, West Nile virus, and dengue virus

Wu,

Zhang,

Qiang

et al. 2024

Reviews in Medical Virology

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Arthropod‐borne viruses (arboviruses) pose significant threats to global public health by causing a spectrum of diseases ranging from mild febrile illnesses to severe neurological complications. Understanding the intricate interplay between arboviruses and the immune system within the central nervous system is crucial for developing effective strategies to combat these infections and mitigate their neurological sequelae. This review comprehensively explores the mechanisms by which arboviruses such as Zika virus, West Nile virus, and Dengue virus manipulate immune responses within the CNS, leading to diverse clinical manifestations.

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Section: Immunomodulatory Strategiesmentioning

confidence: 87%