Studies of adrenergic mechanisms inrelation to histamine sensitivity in children immunized with Bordetella pertussis vaccine

Sen, D.; Arora, Satish; Gupta, Satya P.; Sanyal, R. K.

doi:10.1016/s0091-6749(74)80005-9

Cited by 32 publications

(13 citation statements)

References 11 publications

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“…Furman et al (25) have shown that plasma insulin concentrations were significantly higher in children with pertussis than in a group of controls; however, plasma glucose concentrations were normal in the two groups. Sen et al (26) observed that DTP-vaccinated children had a blunted hyperglycemic response to epinephrine, and Hannik and Cohen (27) found that infants who received a concentrated pertussis vaccine (16 opacity units per dose) had significantly higher plasma insulin concentrations 8 h after vaccination than controls who received diphtheria and tetanus toxoid-polio immunization. Recently Sekura et al (28) noted elevated insulin concentrations in four of 76 adult 'volunteers who received an experimental pertussis vaccine composed of purified LPF inactivated with hydrogen peroxide.…”

Section: Discussionmentioning

confidence: 99%

Metabolic and Hematologic Effects and Immune Complex Formation Related to Pertussis Immunization

et al. 1990

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ABSTRACT. Selected metabolic, hematologic, and immunologic functions were evaluated in 3-to 6-mo-old Finish infants who received whole-cell pertussis-component diphtheria and tetanus toxoids and pertussis vaccine, adsorbed (DTP) vaccine, and in 4-to 6-y-old Los Angeles children who received either a licensed DTP va-ccine or an acellular pertussis component DTP vaccine. One d after immunization, there was an increase in total leukocytes and neutrophils and a decrease in lymphocytes in all vaccinees. In 4-to 6-y-old children the leukocytosis and neutrophilia were greater in recipients who received the standard DTP vaccine than in vaccinees who received an acellular pertussis component DTP vaccine. In infants there was an increase in the mean plasma insulin concentration but no change in the glucose concentration 24 h after immunization; no increase in the mean plasma insulin was noted in the 4-to 6-y-old children. Three 4-to 6-y-old vaccinees had higher circulating immune complex concentrations after immunization and two of these children had high clinical reaction scores. The etiology of adverse reactions after DTP immunization is multifactorial. In contrast with findings in animals, our findings do not demonstrate a clinically significant effect due to lymphocytosispromoting factor on glucose metabolism in vaccinated children. Neutrophilia in vaccinees is probably due to endotoxin, and some reactions may be due to circulating immune complexes. (Pediatu Res 27: 353-357,1990) Abbreviations AHG Eq, aggregated human gammaglobulin equivalent APDT, acellular pertussis component DTP vaccine CI, confidence interval CIC, circulating immune complexes DTP, diphtheria and tetanus toxoids and pertussis vaccine, adsorbed FHA, filamentous hemagglutinin LPF, lymphocytosis-promoting factor LPS, lipopolysaccharide WBC, white blood cell kocytosis with a predominant lymphocytosis, and marked adjuvancy in several immunologic systems (1-4). These effects are primarily due to the Bordetella pertussis antigen LPF but LPS (endotoxin) may also contribute to the metabolic, hematologic, and immunologic findings.Many adverse clinical events occur after pertussis immunization in children, but the pathophysiology of these events is not well understood (1,2, 5). It has been suggested that some of these adverse events may be due to biologically active LPF and LPS that are present in routinely used DTP vaccines. There are, however, few data available that indicate that these antigens are in sufficient concentration in presently used DTP vaccines to produce hematologic or metabolic changes in vaccinated children.In Japan, acellular pertussis vaccines have been used for the routine immunization of children since 198 1 (6-8). These vaccines contain significantly reduced amounts of LPS and biologically active LPF, and their use has been associated with fewer vaccination side effects than occur in whole-cell pertussis vaccine recipients. Because of the paucity of information relating to hematologic and metabolic effects and immune complex formatio...

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Section: Discussionmentioning

confidence: 99%

Metabolic and Hematologic Effects and Immune Complex Formation Related to Pertussis Immunization

et al. 1990

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“…To summarize, histamine sensitization in mice in response to B. pertussis infection was first described over 50 years ago (606). Subsequently, histamine sensitization was studied by many investigators, but only five studies involving humans were carried out (269,486,501,561,574,576,618,622,625,686,701,801). In a 1948 study, Parfentjev and Goodline found that mice injected intraperitoneally with a pertussis vaccine subsequently became hypersensitive to histamine challenge; 2 mg of histamine had similar lethality in sensitized (previously vaccinated) mice as did 50 mg in unvaccinated mice (606).…”

Section: Virulence Determinantsmentioning

confidence: 99%

Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due toBordetella pertussisand OtherBordetellaSubspecies

2005

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Bordetella respiratory infections are common in people (B. pertussis) and in animals (B. bronchiseptica). During the last two decades, much has been learned about the virulence determinants, pathogenesis, and immunity of Bordetella. Clinically, the full spectrum of disease due to B. pertussis infection is now understood, and infections in adolescents and adults are recognized as the reservoir for cyclic outbreaks of disease. DTaP vaccines, which are less reactogenic than DTP vaccines, are now in general use in many developed countries, and it is expected that the expansion of their use to adolescents and adults will have a significant impact on reducing pertussis and perhaps decrease the circulation of B. pertussis. Future studies should seek to determine the cause of the unique cough which is associated with Bordetella respiratory infections. It is also hoped that data gathered from molecular Bordetella research will lead to a new generation of DTaP vaccines which provide greater efficacy than is provided by today's vaccines

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“…In humans adjuvant activity of B. pertussis has been demonstrated [8]. Vaccination with B. pertussis resulted in ^-adrenergic blocking effects of adrenaline-induced hy perglycemia, isoprenaline-induced heart rate changes and histamine-induced wheals [18]. Corynebacterium pcirvum also enhanced the sensitivity to histamine in certain rat strains [1].…”

Section: Discussionmentioning

confidence: 99%

Mast Cells as a Possible Source of <i>Haemophilus influenza</i><i>e</i>-Induced Changes in Plasma and Lung Histamine Levels

Raaijmakers¹,

Terpstra²,

Kreukniet³

1980

Int Arch Allergy Immunol

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Histidine decarboxylase activity and histamine levels of peritoneal mast cells were enhanced 4 days after intraperitoneal Haemophilus influenzae vaccination of rats. Incubation of the cells with propranolol (3.4 × 10^––⁴M) resulted in histamine release and an increased histidine decarboxylase activity. Histidine decarboxylase activity and histamine release were more increased in the presence of propranolol in mast cells obtained from H. influenzae-vaccinated rats. An increased mediator release is also suggested by the increase of the number of peritoneal eosinophils. These data might explain the earlier observed enhanced plasma and lung histamine levels in H. influenzae-vaccinated rats.

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Studies of adrenergic mechanisms inrelation to histamine sensitivity in children immunized with Bordetella pertussis vaccine

Cited by 32 publications

References 11 publications

Metabolic and Hematologic Effects and Immune Complex Formation Related to Pertussis Immunization

Metabolic and Hematologic Effects and Immune Complex Formation Related to Pertussis Immunization

Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due toBordetella pertussisand OtherBordetellaSubspecies

Mast Cells as a Possible Source of <i>Haemophilus influenza</i><i>e</i>-Induced Changes in Plasma and Lung Histamine Levels

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