Studies of Anti-Cytomegalovirus IgG Antibody Positive Rate and Cytomegalovirus Mononucleosis in Adults

Abstract

We analyzed anti-Cytomegalovirus (CMV) IgG and IgM antibody (EIA) and anti-Epstein-Barr virus (EBV) viral capsid antigen (VCA) IgG and IgM antibody (FA) in adults during 1994-1999. We examined these IgM sero-positive patient's medical records, and diagnosed CMV mononucleosis and EBV mononucleosis. Anti-CMV antibody positive rates decreased from 87.6% in 1994 to 77.8% in 1999. Especially in twenties, anti-CMV antibody positive rates decreased from 65.2% in 1994 to 53.3% in 1999. On the other hand, anti-EBV VCA antibody positive rates were not changed (91-94%). Number of cases of CMV mononucleosis increased from 2 cases in 1994 to 16 cases in 1999, but EBV mononucleosis was not changed. These results suggested that increasing cases of CMV mononucleosis was influenced by decreasing anti-CMV antibody positive rate.

Oral valganciclovir <i>versus</i> intravenous ganciclovir as preemptive treatment for cytomegalovirus infection after living donor liver transplantation: A randomized trial

“…Second, our preoperative examination did not include serologic CMV antibody status of either the recipients or donors; therefore we had no information on high-risk recipients with recipient-negative and donor-positive CMV serostatus. With regard to this point, however, CMV is endemic in Japan (81.7% of adults were CMV IgG positive (18), which suggests that almost all of the recipients in the present study were likely CMV IgGpositive (19). Third, this study was a not a multi-center, double-blinded study.…”

Six Cases of Infectious Mononucleosis by Cytomegalovirus as Diagnosed by Multiplex Virus PCR Assay

“…The positive detection rate of anti-CMV antibody in Japanese people, most of whom were infected with the virus during infancy was high being 80 to 90% [14], and higher than that among people in the United States [15]. In recent years, however, positive detection rate of the antibody among young Japanese people has decreased to around 60%, possibly because of decreased horizontal infection in infancy [14].…”

“…In recent years, however, positive detection rate of the antibody among young Japanese people has decreased to around 60%, possibly because of decreased horizontal infection in infancy [14]. Therefore, the incidence of CMV-IM, which was low when compared with that of EBV-IM, is assumed to have increased in recent years [14].…”

Severe Steroid-resistant Thrombocytopenia Secondary to Cytomegalovirus Infection in an Immunocompetent Adult

“…Other studies have reported a recent decrease in the prevalence of the anti-CMV antibody, particularly in young adults (18,19). Consequently, the number of cases of acute CMV infection in immunocompetent adults appears to be increasing, along with an increase in the incidence of severe complications.…”