Studies of ascorbate-dependent, iron-catalyzed lipid peroxidation

Miller, Dennis M.; Aust, Steven D.

doi:10.1016/0003-9861(89)90261-0

Cited by 248 publications

(90 citation statements)

References 23 publications

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“…The turning point was reported to lie between a curcumin concentration of 0.61 and 2.70 mM and depends on the type of substrate used to measure •OH production/scavenging (Kunchandy and Rao, 1990). It was further demonstrated that curcumin, just as ascorbic acid (Miller and Aust, 1989), is capable of reducing transition metals such as Fe 3+ in a concentration-dependent manner (Kunchandy and Rao, 1989;Tønnesen and Greenhill, 1992). In fact, curcumin was more effective in reducing Fe 3+ than ascorbic acid at equimolar concentrations (Reddy and Lokesh, 1994).…”

Section: •-mentioning

confidence: 97%

“…Subsequent studies, which focused on the Fenton component only, revealed that curcumin in aqueous solution exhibits a Jekyll and Hyde-type of ROS personality that is comparable to ascorbic acid (Miller and Aust, 1989), namely one with both antioxidative and pro-oxidative properties (Kunchandy and Rao, 1990). At higher concentrations, curcumin behaves as an antioxidant, whereas at lower concentrations it acts as a pro-oxidant.…”

Section: •-mentioning

confidence: 99%

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The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

Golen²,

et al. 2013

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Section: •-mentioning

confidence: 97%

Section: •-mentioning

confidence: 99%

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

Golen²,

et al. 2013

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“…MDA content was measured by previous published thiobarbituric acid assay of Miller and Aust [14] with some modification. The reaction mixture containing 0.2 mL of tissue homogenate, 0.2 mL 8.1% sodium dodecyl sulfate (SDS), 1.5 mL 20% acetic acid buffer (pH 3.5), 1.5 mL 1% TBA, and 1 mL distilled water was heated at 90˚C for 90 min, then cooled at room temperature and centrifuged for 15 min at 3,000 rpm/min.…”

Section: Degree Of Lipid Peroxidation Determined Using Malondialdehydmentioning

confidence: 99%

Time-Effect Relationship of Toxicity Induced by Roundup® and Its Main Constituents in Liver of Carassius Auratus

Fan¹,

Geng

Ren³

et al. 2013

CWEEE

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“…Infant formulas contain polyunsaturated fatty acids, iron and ascorbic acid. As ascorbic acid is known to possess both antiand pro-oxidant e#ects, some authors have suggested that dose-dependent lipid peroxidation occurs in the presence of iron 14), 15) . They indicated that the prooxidant e#ect of ascorbic acid was related to the ability of ascorbic acid to promote the formation of a Fe(II) : Fe (III) complex required for iron-catalyzed lipid peroxidation.…”

Section: Formation Of Furan During Incubation For Equilibrationmentioning

confidence: 99%

Rapid and Improved Determination of Furan in Baby Foods and Infant Formulas by Headspace GC/MS

Yoshida

Isagawa²,

Kibune³

et al. 2007

J. Food Hyg. Soc. Jpn

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Furan is a 5-membered ring compound with high volatility. The U.S. Food and Drug Administration (FDA) has recently published a report on the occurrence of furan in a large number of thermally processed foods. However, the FDA's analytical method, using standard curve addition, is not suitable for high-throughput routine laboratory operations. We developed a rapid and improved method for determination of furan in foods by headspace GC/MS. Quantification was achieved by using an internal standard of d 4 -furan and an external calibration curve of furan normalized against the internal standard. The incubation temperature for equilibration was set at 60῍ to avoid the formation of furan during analysis. The levels of furan in baby foods and infant formulas were determined with this method. Validation data showed good precision and accuracy. The LOD and LOQ were 0.2ῌ0.5 ng/g and 0.5ῌ2 ng/g for various food matrixes, respectively. The level of furan detected was in the range of 1.4 to 90 ng/g in baby foods and in the range of non-detectable to 36 ng/g in infant formulas.Key words: furan; headspace; gas chromatography-mass spectrometry; baby food; infant formula Introduction Furan (C 4 H 4 O) is a colorless, volatile (boiling point 31῍) and lipophilic organic compound 1) . It is considered to be a hazardous chemical and is classified by the International Agency for Research on Cancer (IARC) as possibly carcinogenic to humans (group 2B; IARC) 2) . The U.S. Food and Drug Administration (FDA)῍ 1 has recently published a report on the occurrence of furan in a large number of thermally processed foods, such as canned and jarred foods, including baby foods and infant formulas. The FDA analyzed approximately 340 food samples and found furan levels ranging from non detectable to approximately 170 ng/g. The Swiss Federal O$ce of Public Health has presented an analytical method for the determination of furan in foodstu#s and used it to measure furan levels in a variety of foods on the Swiss market 3) . The European Food Safety Authority (EFSA) 4) has recently published a report on furan, in which they concluded that a more detailed risk assessment was required.The primary source of furan in food was considered to be thermal degradation of carbohydrates, such as glucose, lactose and fructose 5) . Perez-Locas and Yaylayan suggested that ascorbic acid had the highest potential to produce furan on thermal treatment, followed by some sugar/amino acids mixtures 6) . Health Canada has recently reported the formation of furan via the oxidation of polyunsaturated fatty acids at elevated temperatures, and from the decomposition of ascorbic acid derivatives 7) . Fan has recently studied the formation of furan from sugars, ascorbic acid and organic acids under the influence of ionizing radiation and thermal treatments 8) . It was reported that the pH and concentration of sugars and ascorbic acid solution profoundly influenced furan formation during irradiation or thermal treatment.As furan is a small, volatile molecule, headspace gas chrom...

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Studies of ascorbate-dependent, iron-catalyzed lipid peroxidation

Cited by 248 publications

References 23 publications

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

Time-Effect Relationship of Toxicity Induced by Roundup® and Its Main Constituents in Liver of Carassius Auratus

Rapid and Improved Determination of Furan in Baby Foods and Infant Formulas by Headspace GC/MS

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Studies of ascorbate-dependent, iron-catalyzed lipid peroxidation

Cited by 248 publications

References 23 publications

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

Time-Effect Relationship of Toxicity Induced by Roundup&#174; and Its Main Constituents in Liver of Carassius Auratus

Rapid and Improved Determination of Furan in Baby Foods and Infant Formulas by Headspace GC/MS

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Product

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About

Time-Effect Relationship of Toxicity Induced by Roundup® and Its Main Constituents in Liver of Carassius Auratus