Studies of bladder stone disease in Thailand. XVII. Effect of exogenous source of oxalate on crystalluria

Valyasevi, Aree; Dhanamitta, Sakorn

doi:10.1093/ajcn/27.8.877

Cited by 19 publications

(7 citation statements)

References 15 publications

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“…An excessive intake of oxalate has been im plicated in the formation of calcium oxalate stones. in some Asian countries (Singh, Kothari, Sharma & Saxena, 1972;Valyasevi & Dhanamitta, 1974) but most of our patients had a normal oxalate intake, the only exceptions being one or two heavy beer and tea drinkers. An increased endogenous synthesis of oxalate likewise appears to be a rare cause of hyperoxaluria among stone-formers, occurring notably in the inherited condition, primary hyperoxaluria (Williams & Smith, 1972).…”

Section: Discussionmentioning

confidence: 56%

Evidence of Increased Oxalate Absorption in Patients with Calcium-Containing Renal Stones

Hodgkinson

1978

Clinical Science

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1. The possible roles of the diet and of intestinal absorption in the increased excretion of oxalate by patients with renal calcium stones have been studied. 2. Dietary surveys showed that the mean daily intake of oxalic acid by stone-formers was not significantly different from that of non-stone-formers. 3. The mean urinary excretion of oxalate, expressed as an oxalate/creatinine molar ratio, was significantly reduced by fasting, the change being more marked in the stone-formers than in the normal subjects. Moreover, fasting abolished the difference in mean oxalate/creatinine ratios between stone-formers and control subjects. 4. These results are compatible with the hypothesis that the small increases in urinary oxalate excretion which occur in some idiopathic calcium oxalate stone-formers are due to increased absorption of oxalate from the intestine, which may be due to a reduction in intraluminal calcium concentration.

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Section: Discussionmentioning

confidence: 56%

Evidence of Increased Oxalate Absorption in Patients with Calcium-Containing Renal Stones

Hodgkinson

1978

Clinical Science

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“…Bladder and urethral stones constituted 89.3% of the cases; 53.6% of these stones were reported in children aged ≤ 10 years and 89.1% of pediatric patients with vesical stones were male. Epidemiologic studies about stone disease in populations that included pediatric group have been conducted in Thailand [80][81][82][83][84][85][86][87][88][89][90][91][92]. These studies evaluated the effects of some special milk supplements on urine composition of infants [82], effects of exogenous source of oxalate on crystalluria [83], and effects of dietary habits on stone disease prevalence [84,92].…”

Section: Southeast Asiamentioning

confidence: 99%

Urolithiasis in Asian children: Evaluation of metabolic factors

Naseri

2016

J Pediatr Biochem

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This study was conducted to review urolithiasis in Asian children with a focus on urinary metabolic factors. A literature search of Pub Med and Google identified pertinent articles from 20 different Asian countries which were subsequently reviewed. A totally of 12.913 children (M/F ratio of 2.37/1) were enrolled in the studies. Hypercalciuria, hyperuricosuria, hyperoxaluria, hypocitraturia and decreased urinary magnesium excretion were reported in 652 of 4509 (14.45%), 276 of 3137 (8.8%), 1053 of 3973 (26.5%), 1940 of 2846 (68.2%), 32 of 240 (13.3%) of subjects, respectively. Cystinuria was noted in 112 of 4106 (2.7%) and mixed metabolic abnormalities were found in 175 of 724 (24.2%) patients. Association of urinary tract infection with stone disease was common in our series [2454 of 6430; (38.16) cases]. Urologic abnormalities were uncommon and recorded in only 447 of 9788 patients (4.5%). The etiology of stone formation was idiopathic in 731 of 2731 (26.8%) patients. Analysis of 3977 stones indicated that 983 (24.9%) were pure Ca stones, whereas 1579 (40%), 411 (10.4%), 38 (0.95%) and 288 (7.35%) were mixed Ca, uric acid or urate, cystine and struvite stones respectively. The study showed that hypocitraturia and hyperoxaluria are the most common metabolic abnormalities. Overall, calcium was the main component of stones with the except that bladder stones were composed of urate or uric acid alone or in combination with calcium. In addition, uric acid stones which are uncommon among American children were frequently reported in Asian children.

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“…Figures 2 and 3 show that both the volume of calcium oxalate crystals and the proportion of large calcium oxalate crystals and aggre gates in the urine of stone-formers are highly related to the urinary concentration of oxalate. It is well documented that the frequent passage of such crystals increases the risk of stones in the population [37,40,47,48,52,53] 3 also show that there is little or no relationship between calcium oxalate crystalluria and urinary calcium concen tration.…”

Section: The Mechanism By Which Mild Hyperoxaluria Increases the Riskmentioning

confidence: 99%

The Cause of Idiopathic Calcium Stone Disease: Hypercalciuria or Hyperoxaluria?

Robertson

Peacock²

1980

Nephron

270

118

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Hypercalciuria is common in patients who form calcium oxalate urinary stones and is considered by many to be the cause ofthe disorder. This review shows that there is little relationship between either the rate of stone-formation or calcium oxalate crystalluria and the urinary excretion of calcium. There is, however, a strong relationship between these parameters and the urinary excretion of oxalate which is slightly, but significantly, elevated in stone-formers compared with normals. It is concluded that this mild degree of hyperoxaluria may be much more important than hypercalciuria in the genesis of calcium oxalate stones.

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Studies of bladder stone disease in Thailand. XVII. Effect of exogenous source of oxalate on crystalluria

Cited by 19 publications

References 15 publications

Evidence of Increased Oxalate Absorption in Patients with Calcium-Containing Renal Stones

Evidence of Increased Oxalate Absorption in Patients with Calcium-Containing Renal Stones

Urolithiasis in Asian children: Evaluation of metabolic factors

The Cause of Idiopathic Calcium Stone Disease: Hypercalciuria or Hyperoxaluria?

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