“…Later studies implicated other "primary" factors such as distribution of blood (Folkow, 1962;Longerbeam et al, 1962;Gourzis and Nickerson, 1965); individual organ blood flow and function (Selkurt, 1946;Selkurt et al, 1947;Baez et al, 1951;Lillehei, 1957;Rayner et al, 1960;Frank et al. 1962); destruction changes in the microcirculation (Zweifach, 1958;Hinshaw £t al., 1962;; and change in blood volume and vascular capacitance (Nelson et al, 1947;Lewis and Mellander, 1962). The effect of bacterial toxins as a "primary" factor of shock was given attention by Fine (1954), Weil et (1956), and Visscher (iy58), mecabolic aciùosla (HuuLaLae, 135Sa;Manger £t ol., 1962), proteo lytic lysozymes, and the results of visceral ischemia were also studied (Selkurt, 1959;Lillehei, 1960).…”