Studies of Depressant Action of Purine Nucleotides on Cholinergic Nerve in Guinea-Pig Ileum

Mori, Motokuni; Yamada, Shizuo; Eiichi, Hayashł

doi:10.1016/b978-0-08-021308-8.50454-3

Cited by 3 publications

(4 citation statements)

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“…In intact intestinal tissues, ATP and adenosine have been shown to inhibit the release of acetylcholine from cholinergic nerves (Takagi & Takayanagi, 1972;Mori, Yamada, Takamura & Hayashi, 1973;Vizi & Knoll, 1976). Concentration-dependent ATP-induced contraction and inhibition of cholinergic twitches of the guinea-pig small intestine have also been reported .…”

Section: Discussionmentioning

confidence: 94%

The nature of non‐cholinergic, non‐adrenergic transmission in longitudinal and circular muscles of the guinea‐pig ileum

Bauer

Kuriyama

1982

The Journal of Physiology

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Section: Discussionmentioning

confidence: 94%

The nature of non‐cholinergic, non‐adrenergic transmission in longitudinal and circular muscles of the guinea‐pig ileum

Bauer

Kuriyama

1982

The Journal of Physiology

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“…Since adenosine did not appear to change the presynaptic spike or postsynaptic membrane resistance of the soma, adenosine apparently acts somewhere in the vicinity of the LOT synapses onto dendrites. Adenosine could reduce the release of excitatory transmitter as is the case at the neuromuscular junction (Ribeiro & Walker, 1975) and in the ileum (Mori, Yamada & Hayashi, 1975). However, the mechanism of adenosine action is not clear.…”

Section: Theophylline Actionmentioning

confidence: 99%

“…Adenosine could reduce the release of excitatory transmitter as is the case at the neuromuscular junction (Ribeiro & Walker, 1975) and in the ileum (Mori, Yamada & Hayashi, 1975). However, the mechanism of adenosine action is not clear.…”

Section: Theophylline Actionmentioning

confidence: 99%

Depression of Evoked Potentials in Brain Slices by Adenosine Compounds

Scholfield

1978

British J Pharmacology

119

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1 A study has been made of the action of adenosine on surface slices of guinea-pig olfactory cortex in vitro.2 With extracellular recordings from the pial surface and stimulation of the presynaptic input, the lateral olfactory tract (LOT) generated a monosynaptic negative wave representing dendritic excitatory potentials. This negative wave was depressed by bath application of 1 gAM adenosine with increasing effect up to 1 mm. Adenosine 5'-triphosphate (ATP), adenosine 5'-monophosphate (AMP) and cyclic adenosine 3',5'-monophosphate (cyclic AMP) had similar depressant actions.Adenine and guanosine were very weak depressants. 3 Theophylline concentrations in the range 10 gM to 3 mm progressively antagonized the action of adenosine. 4 Dibutyryl cyclic AMP (100 gM) and agents which increase intracellular cyclic AMP were not depressants, suggesting that the action of adenosine was not cyclic AMP-mediated. 5 Intracellular recordings confirmed the depressant effect of adenosine on excitatory potentials generated by LOT stimulation and also showed that postsynaptic action potentials and the membrane of the soma were unaffected by adenosine. 6 Since presynaptic action potentials were also unaffected by adenosine, these experiments suggest that adenosine reduces excitatory transmission at LOT synapses and fortifies the idea that adenosine has a 'neurohumoral' action.

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“…4, it was assumed that the intrinsic acetylcholine released from the nervous tissue of the ileum may be involved in the "TPS effect" . To confirm this assumption we employed tetrodotoxin (5, 6) adenosine (7) and an anoxic condition (8) .…”

Section: Influence Of Tps On the Contraction To Acetylcholine And Hismentioning

confidence: 99%

Enhancement of 5-Hydroxytryptamine-Induced Contraction of the Guinea Pig Ileum by a New Sulfur Compound, Tripropylsulfonium Bromide

Yoshimura

Takamura

Ishikawa

et al. 1978

Japanese Journal of Pharmacology

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Studies of Depressant Action of Purine Nucleotides on Cholinergic Nerve in Guinea-Pig Ileum

Cited by 3 publications

References 0 publications

The nature of non‐cholinergic, non‐adrenergic transmission in longitudinal and circular muscles of the guinea‐pig ileum

The nature of non‐cholinergic, non‐adrenergic transmission in longitudinal and circular muscles of the guinea‐pig ileum

Depression of Evoked Potentials in Brain Slices by Adenosine Compounds

Enhancement of 5-Hydroxytryptamine-Induced Contraction of the Guinea Pig Ileum by a New Sulfur Compound, Tripropylsulfonium Bromide

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