Studies of growth hormone (GH), Thyrotropin (TSH) and prolactin (PRL) secretion in anorexia nervosa

Macaron, Chamel; Wllber, John F.; Green, Orville; Freinkel, Norbert

doi:10.1016/0306-4530(78)90006-9

Cited by 43 publications

(7 citation statements)

References 14 publications

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“…Walsh et al (1978) found abnormal cortisol secretion patterns in anorexics, and other hypothalamic-pituitaryadrenal endocrine regulatory disturbances, such as dexamethasone nonsuppression, have been demonstrated in patients with anorexia nervosa (Garfinkel et al, 1981;Bethage et al, 1970;Walsh et al, 1978;Gerner & Gwirtsman, 1981) or bulimia (Gwirtsman et al, 1983;Hudson et al, 1983). In addition, an abnormal TSH response to TRH, a delay in peak TSH response to TRH (Casper & Frohman, 1982), a delay in fall of TSH (Croxson & Ibbertson, 1977) and a blunted TSH response (Macaron et al, 1978) have been demonstrated in anorexics. Gwirtsman et al (1983) have reported a blunted TSH response to TRH in bulimic patients as well.…”

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confidence: 99%

Impairment of taste perception in anorexia nervosa and bulimia

Jirik-Babb

Katz

1988

Int. J. Eat. Disord.

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Nine women diagnosed as having primary anorexia nervosa (ANs), five women diagnosed as having bulimia (Bs), and seven normal control women (NCs) were tested for perception of taste quality and intensity using the method of magnitude estimation. The four taste stimuli used were sucrose, hydrochloric acid (HCI), sodium chloride (NaCl), and quinine hydrochloride (QHCI). Four different log molar concentrations of each of these four taste stimuli were employed. No significant differences were found among the three groups in ability to identify taste quality. However, there were significant differences (p <.05) in magnitude estimates of the 3 higher concentrations of the HCI solution, the 2 higher concentrations of the sucrose and NaCl solutions, and the QHCl solution of the highest concentration. The magnitude estimates of the ANs and Bs were consistently lower than those of the NCs. The results indicate that poor gustatory sensitivity is significantly associated with the abnormal eating behavior characteristic of both anorexia nervosa and bulimia.

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confidence: 99%

Impairment of taste perception in anorexia nervosa and bulimia

Jirik-Babb

Katz

1988

Int. J. Eat. Disord.

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“…It is worth mentioningthat 1 subject responded to TRH by releasing both FSH and LH. A moderate rise in FSH afterTRH in 1 of8 patients with AN had been previously reported by Lundberg et al [1972], Prolactin levels are within the normal range under basal conditions in AN [Beau mont el al.. 1974;Macaron et al, 1978;Maeda et al. 1976], although higher PRL levels than in controls have occasionally been noted [Travaglini et al, 1976], In our study, basa) PRL levels were within the normal range in 8 of 10 patients and low in 2.…”

Section: Control Subjectsmentioning

confidence: 49%

“…baseline PRL levels within the normal range [Macaron ct al.. 1978;Maeda ct al.. 1976; this study], or elevated [Travaglini et al, 1976] and the normal [Macaron et al. 1978;Maeda et al.…”

Section: Control Subjectsmentioning

confidence: 99%

“…An analysis of anomalous AP responsive ness to hypophysiotropic stimuli as related to basal hormone titers might give insight into the pathophysiology of AN, a syndrome in which the possibility of hypothalamic abnor mality has been postulated and proved [Mecklenburg et al, 1974], Macaron et al [1978] reported significant increases in circulating GH concentrations following TRH only in patients whose basal GH concentrations were elevated. No such correlation was present in Gold et al [1980] or our study, cither after TRH or LH-RH stimulations.…”

Section: Control Subjectsmentioning

confidence: 99%

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Anterior Pituitary Responsiveness to Hypothalamic Hormones in Anorexia Nervosa

Brambilla¹,

Nobile²,

Müller

1981

Neuropsychobiology

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7 women and 3 men with anorexia nervosa were tested with thyrotropin-releasing hormone (TRH) and luteinizing hormone-follicle stimulating hormone-releasing hormone (LH-RH) and the growth hormone (GH), prolactin (PRL), gonadotropin (FSH-LH) and thyrotropin (TSH) responsiveness of their anterior pituitaries (AP) to the two hypothalamic neurohormones were determined. Administration of TRH (500 µg i.v.) induced rises in plasma GH in 4 patients, while in 4 patients it induced rises in plasma FSH and/or LH. LH-RH (150 µg i.v.) induced rises in plasma GH in 3 patients, increased plasma PRL in 3 patients and plasma TSH in 1 patient. Collectively, in only 1 patient, who was in a phase of initial nutritional rehabilitation, was there conventional AP responsiveness to hypothalamic neurohormones. This demonstrates that there is a profound derangement of AP responsiveness to hypothalamic neurohormones in patients with anorexia nervosa, probably reflecting a primary alteration in brain neurotransmitter function.

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“…Both low urine MHPG (Schildkraut, 1965;Fawcett, Maas, & Dekirmenjian, 1972) and DST non-suppression (Carroll, Feinberg, Greden, Tarika, Albala, Haskett, James, Kromfoe, Lohr, Steiner, Devigne, & Young, 1981) have been reported in patients with major depression. In addition, blunted TSH and exaggerated GH responses to TRH stimulation have been reported in both AN (Macaron, Wilber, Green, & Freinkel, 1978;Gold, Pottash, Martin, Finn, & Davies, 1980-81) and depression (Maeda, Kato, Ohgo, Chihara, Yoshimoti, Yamaguchi, Kuromara, & Imura, 1975;Targum, Sullivan, & Byrnes, 1982).…”

Section: Weight and Depressionmentioning

confidence: 99%