A survey was conducted on a sample of 159 Australian bus drivers to determine the extent to which workload and self-reported driver coping styles predicted their subjective health status. The model that was proposed incorporated the hours spent driving as a measure of workload, both adaptive and maladaptive driver coping styles, and self-report measures of need for recovery (i.e., fatigue), positive and negative affect, and physical symptoms. Results of hierarchical regression analyses revealed that the workload was a significant predictor of drivers' need for recovery but not of their positive and negative affect nor of their physical symptoms. Need for recovery was in turn a significant predictor of positive and negative affect and of their physical symptoms indicating that it mediates the influence of workload on positive and negative affect and physical symptoms. Two maladaptive coping strategies added to the prediction of need for recovery, as well as to the prediction of negative affect, even after controlling for the influence of need for recovery. One adaptive coping strategy added to the prediction of positive affect. Strategies for management of fatigue in bus drivers should focus on the assessment and remediation of maladaptive coping strategies which impact of drivers' need for recovery which in turn predicts positive and negative affect and physical symptoms.