Studies of Hepatic Excretory Function

Gj, Kleiner; Kresch, L; Im, Arias

doi:10.1056/nejm196508192730804

Cited by 63 publications

(3 citation statements)

References 11 publications

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“…The impairment has been attributed to changes in glucose absorption ( S ) , in gut insulin-releasing factors ( 6 ) , in liver function (7,8), to increase insulin resistance of the peripheral tissues (9) and to elevation of plasma glucocorticoids (10) and growth hormone (11).…”

mentioning

confidence: 99%

Oral Contraceptives, Norethynodrel and Mestranol: Effects on Glucose Tolerance, Tissue Uptake of Glucose-U-14C and Insulin Sensitivity

Lei¹,

Yang²

1972

Experimental Biology and Medicine

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mentioning

confidence: 99%

Oral Contraceptives, Norethynodrel and Mestranol: Effects on Glucose Tolerance, Tissue Uptake of Glucose-U-14C and Insulin Sensitivity

Lei¹,

Yang²

1972

Experimental Biology and Medicine

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“…Oestrogen administration in large doses has been reported to 1964) but not in doses of 2.5 mg oestradiol daily for ten days in women of childbearing age (Kleiner et al, 1965). In five out of nine subjects following methylated oestradiol administration a moderately increased reversible B.S.P.…”

Section: Discussionmentioning

confidence: 94%

Oestrogen, Progestogen and Liver‐function Tests

Eisalo¹,

Heino²,

Räsänen³

1968

Acta Obstet Gynecol Scand

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When considering the reason for the abnormal liver-function tests in subjects to whom oral contraceptives have been administered it has been suggested that either the oestrogen or the progestogen component is responsible for the changes in these tests (Adlercreutz, 1964; Eisalo et al., 1964; Boake et nl., 1965; Stoll et al., 1966) or that a synergetic action of the two components takes place (Borglin, 1965; Eisalo et al., 1965).The present study concerns liver-function tests in subjects who have received synthetic oestrogen, progestin and their combinations. Synthetic steroids widely used as oral contraceptives were employed in the study. Subjects and MethodsThe series consisted of 40 postmenopausal women divided into four groups, each comprising 10 subjects. For 28 consecutive days the first group was administered daily 0.15 mg of mestranol (3-methoxy-l7a-ethinyloestradiol), the second group 5 mg of lynoestrenol (1 7a-ethinyloestrenol), the third 0.05 mg of 17aethinyloestradiol, and the fourth 4 mg of megestrol acetate (1 7a-acetoxy-6-methylpreg-4.6-dien-3.20-dione). One woman refused to take mestranol on trial. After the initial phase the experiment was continued for a consecutive period of 28 days by combining the treatment in the oestrogen groups with the progestin compound and in the progestin groups with the

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“…Replacement of the Cl in 5 with different amines resulted in the 5-substituted aminobenzisothiazoles (10)(11)(12)(13)(14)(15)(16)(17)(18)(19) (Table II). For the reaction with benzylamine the corresponding benzisothiazoline 7 was formed as by-product.…”

Section: Methodsmentioning

confidence: 99%