Studies of Human and Rat Blood under Oxidative Stress: Changes in Plasma Thiol Level, Antioxidant Enzyme Activity, Protein Carbonyl Content, and Fluidity of Erythrocyte Membrane

Yelinova, V.I.; Glazachev, Yury; Khramtsov, Valery V.; Kudryashova, Larissa; Рыкова, В. И.; Salganik, R. I.

doi:10.1006/bbrc.1996.0590

Cited by 58 publications

(38 citation statements)

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“…24 It has been hypothesized from experimental studies that RBCs have free radical scavenging (the presence of an abundant amount of powerful anti-oxidant enzymes which help control oxidative stress under normal physiological conditions) and pro-oxidant (redox imbalance in RBCs resulting from overwhelming oxidative damage and inflammation in pathological tissues which alters and overcomes the anti-oxidant mechanisms and, therefore, RBCs function as pro-oxidant cells modifying and regulating distant vascular beds and endothelial function) and signaling properties (oxidative stress causing alteration in RBC membrane properties and the interaction among RBCs and between RBCs and other cells which leads to perpetuation of oxidative damage). 25,26 Oxidative stress can lead to cytoskeleton rearrangement and loss of lipid asymmetry in RBC membranes leading RBCs to become more rigid and asymmetric in size -'anisocytosis'. 27 It has been shown that 'oxidized RBCs' have higher aggregability and adhesiveness to the endothelial tissue leading to a vicious cycle of oxidative damage-induced endothelial dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Red cell distribution width and risk of peripheral artery disease: Analysis of National Health and Nutrition Examination Survey 1999–2004

Zalawadiya¹,

Veeranna²,

Panaich³

et al. 2012

Vasc Med

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Red cell distribution width (RDW) is an independent predictor of the 10-year estimated risk of coronary heart disease (CHD) events. However, RDW's association with peripheral artery disease (PAD) -a CHD risk equivalent -has not been evaluated to date. In this cross-sectional study, we examined 6950 participants of the National Health and Nutrition Examination Survey, 1999Survey, -2004. PAD was defined as an ankle-brachial index below 0.9 (n = 618). RDW was divided into quartiles (Q) (Q1: ≤ 12.2; Q2: 12.3-12.5; Q3: 12.6-13.0; Q4: ≥ 13.1) and PAD risk was compared across these quartiles using adjusted multivariate logistic regression. A graded increase in prevalent PAD with increasing RDW quartiles was observed (4.2% in Q1 vs 13.9% in Q4; test of trend p < 0.001). Risk of PAD was significantly higher (odds ratio (OR) 1.19, 95% confidence interval (CI): 1.06-1.34; p = 0.003) after adjusting for age, sex, race, body mass index, hypertension, hyperlipidemia, diabetes, smoking, estimated glomerular filtration rate, C-reactive protein, hemoglobin, mean corpuscular volume, and nutritional factors (folate, iron and vitamin B 12 ) deficiencies with each unit (0.1) increase in RDW. Upon receiver-operating characteristics analysis, the predictive accuracy of the American College of Cardiology / American Heart Association (ACC/AHA)-defined PAD screening criteria (for a high-risk population) was 0.657 at best, but improved significantly (0.727) after addition of RDW (p < 0.0001). In conclusion, higher levels of RDW are independently associated with a higher risk of PAD and can significantly improve the risk prediction beyond that estimated by ACC/AHA-defined PAD screening criteria.

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Section: Discussionmentioning

confidence: 99%

Red cell distribution width and risk of peripheral artery disease: Analysis of National Health and Nutrition Examination Survey 1999–2004

Zalawadiya¹,

Veeranna²,

Panaich³

et al. 2012

Vasc Med

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“…Both the increase and decrease of trace element ion content can affect the activity of the antioxidant enzymes, including Ca, Cu, and Zn and Se (Yelinova et al, 1996). Statistically significant differences from the normal distribution of Se, Cu and Zn have been reported to occur in patients with various forms of cancers (Trush and Kensler, 1991;Spartz and Bloom, 1992).…”

Section: Discussionmentioning

confidence: 99%

Variation of Urinary and Serum Trace Elements (Ca, Zn, Cu, Se) in Bladder Carcinoma in China

Guo¹,

Zhang²,

Wang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Backgrounds: Deficiency or excess of trace elements can induce body metabolic disorders and cellular growth disturbance, even mutation and cancerization. Since there are few studies of the effect of trace elements in bladder carcinoma in China, the aim of this study was thus to assess variation using a case control approach. Methods: To determine this, 81 patients with bladder carcinoma chosen as a study group and 130 healthy persons chosen as a control group were all assayed for urinary and serum trace elements (calcium [Ca], zinc [Zn], copper [Cu], selenium [Se]) using an atomic absorption spectrophotometer, and the results were analyzed by independent sample t tests. The correlative factors on questionnaires answered by all persons were analyzed by logistic regression. Results: The results showed urinary Ca, Zn and serum Cu levels of the study group to be significantly higher (P<0.05) than those of he control group. Serum Ca and Se levels of study group were significantly lower (P<0.05) than those of control group. Conclusion: There were higher urinary Zn and serum Cu concentrations in bladder carcinoma cases. Bladder carcinoma may be associated with Ca metabolic disorder, leading to higher urinary Ca and lower serum Ca. Low serum Se and smoking appear to be other risk factors for bladder carcinoma in China.

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“…Red blood cells (RBCs), compared with many other cell types, are highly susceptible to ROS generation as hemoglobin (Hb) is a significant source of superoxide generation. 3,4 At the same time, RBCs are equipped with a large supply of anti-oxidant enzymes (superoxide dismutase, catalase, peroxiredoxin, etc.) to combat increased ROS formation which, if left unbalanced, can affect plasma membrane proteins, lipid peroxidation and compromise RBC viability resulting in intra-and extra-vascular lysis.…”

Section: Introductionmentioning

confidence: 99%

Erythroid cells generated in the absence of specific 1-integrin heterodimers accumulate reactive oxygen species at homeostasis and are unable to mount effective antioxidant defenses

et al. 2013

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Studies of Human and Rat Blood under Oxidative Stress: Changes in Plasma Thiol Level, Antioxidant Enzyme Activity, Protein Carbonyl Content, and Fluidity of Erythrocyte Membrane

Cited by 58 publications

References 0 publications

Red cell distribution width and risk of peripheral artery disease: Analysis of National Health and Nutrition Examination Survey 1999–2004

Red cell distribution width and risk of peripheral artery disease: Analysis of National Health and Nutrition Examination Survey 1999–2004

Variation of Urinary and Serum Trace Elements (Ca, Zn, Cu, Se) in Bladder Carcinoma in China

Erythroid cells generated in the absence of specific 1-integrin heterodimers accumulate reactive oxygen species at homeostasis and are unable to mount effective antioxidant defenses

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