Studies of Iodoalbumin Metabolism. Ii. The Effects of Thyroid Hormone*

Lewallen, Charles G.; Rall, J. E.; Berman, Mones

doi:10.1172/jci103798

Cited by 58 publications

(26 citation statements)

References 24 publications

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“…The methods of dialysis of the commercial 1131 labeled human serum albumin employed and details of the injection procedure, collection of blood and urine samples, quantitation of radioactivity in urine and plasma, determination of serum albumin and quantitation of total radioactivity removed in blood sampling have been given elsewhere (2). Stool collections were made only in the case of M. H. in Experiment III.…”

Section: Methodsmentioning

confidence: 99%

“…The individual specimens were suspended in concentrated sodium hydroxide and distilled water to known volume, allowed to digest partly, and then agitated until a uniform pipettable mixture was obtained. The counting procedure was the same as that for urine and plasma (2). None of the patients studied showed albuminuria No chemical fractionation of label was done routinely on urine or plasma samples.…”

Section: Methodsmentioning

confidence: 99%

“…Additional details of the clinical status of the patients and the experimental protocol for Experiment I are given in Reference (2). Features relevant to the present report follow.…”

Section: Methodsmentioning

confidence: 99%

“…After a sufficiently long time lapse, one would expect the final slopes of radioactivity in each compartment and the slope of their sum, the total label retention, to become equal to the slope of the plasma curve. Equality of plasma and retention slopes was not reached in studies carried out to 36 days [Experiment II, (2)]. For this reason fecal and urinary excretion of label, plasma specific activity and label removed in blood sampling were measured in the study of M. H., Experiment III, for 63 days.…”

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confidence: 99%

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Studies of Iodoalbumin Metabolism. I. A Mathematical Approach to the Kinetics*

Lewallen¹,

Berman²,

Rall³

1959

J. Clin. Invest.

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During the clinical study and treatment of a group of patients with thyroid carcinoma, we have studied the effects of thyroid hormone on several metabolic systems under conditions in which the thyroid status of the patients could be controlled at will. Early in the tracer studies of iodoalbumin metabolism in these patients it was apparent that it was necessary to employ a mathematical approach somewhat different from published methods of compartment analysis. Accordingly a suitable mathematical approach was developed by one of the present authors (1). In this report, the practical difficulties encountered in application of the approach to experimental data and the theoretical implications of the approach are discussed.The kinetic analysis of the data of a single tracer study comprises the body of the report. Additional data from other tracer studies are included only insofar as they contribute to the development of the model chosen for analysis. METHODSGeneral. The methods of dialysis of the commercial 1131 labeled human serum albumin employed and details of the injection procedure, collection of blood and urine samples, quantitation of radioactivity in urine and plasma, determination of serum albumin and quantitation of total radioactivity removed in blood sampling have been given elsewhere (2). Stool collections were made only in the case of M. H. in Experiment III. The individual specimens were suspended in concentrated sodium hydroxide and distilled water to known volume, allowed to digest partly, and then agitated until a uniform pipettable mixture was obtained. The counting procedure was the same as that for urine and plasma (2). None of the patients studied showed albuminuria No chemical fractionation of label was done routinely on urine or plasma samples.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…Additional details of the clinical status of the patients and the experimental protocol for Experiment I are given in Reference (2). Features relevant to the present report follow.…”

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Studies of Iodoalbumin Metabolism. I. A Mathematical Approach to the Kinetics*

Lewallen¹,

Berman²,

Rall³

1959

J. Clin. Invest.

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“…Overall, protein synthesis and degradation declines; however, patients with hypothyroidism remain at a positive nitrogen balance. Increased total modifiable albumin pool is seen in myxedema (16). Albumin is distributed to a broad volume, leading to increased capillary wall permeability.…”

Section: The Effect Of Hypothyroidism On Protein Metabolismmentioning

confidence: 99%