Studies of magnesium - hydroxyapatite micro/nano film for drug sustained release

Cao, Jinxing; Liu, Xin; Lian, Ruizhe; Du, Bin; Rogachev, A.V.

doi:10.1016/j.apsusc.2021.150598

Cited by 7 publications

(1 citation statement)

References 28 publications

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“…The most commonly used backbone materials are polymers or bioceramic materials, such as hydroxyapatite (HA). Currently, HA-Mg films are promising for the delivery of ciprofloxacin hydrochloride or norfloxacin [2]. Hydroxyapatite particles are a promising biomimetic alternative or supplement for oral biofilm management, as the films containing HA-Mg (II) exhibit very good bactericidal properties [1,3].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Thin Films Containing Modified Hydroxyapatite Particles and Phospholipids (DPPC) for Improved Properties of Biomaterials

Rojewska,

Adamska,

Kurnatowska

et al. 2023

Molecules

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The main aims of thin biofilm synthesis are to either achieve a new form to promote the transport of drugs in oral delivery systems or as a coating to improve the biocompatibility of the implant’s surface. In this study, the Langmuir monolayer technique was employed to obtain films containing Mg-doped hydroxyapatite with 0.5%, 1.0%, and 1.5% Mg(II). The obtained modified HA particles were analysed via the FT-IR, XRD, DLS, and SEM methods. It was shown that the modified hydroxyapatite particles were able to form thin films at the air/water interface. BAM microscopy was employed to characterized the morphology of these films. In the next step, the mixed films were prepared using phospholipid (DPPC) molecules and modified hydroxyapatite particles (HA-Mg(II)). We expected that the presence of phospholipids (DPPC) in thin films improved the biocompatibility of the preparing films, while adding HA-Mg(II) particles will promote antibacterial properties and enhance osteogenesis processes. The films were prepared in two ways: (1) by mixing DPPC and HA-Mg (II) and spreading this solution onto the subphase, or (2) by forming DPPC films, dropping the HA-Mg (II) dispersion onto the phospholipid monolayer. Based on the obtained π–A isotherms, the surface parameters of the achieved thin films were estimated. It was observed that the HA-Mg(II) films can be stabilized with phospholipid molecules, and a more stable structure was obtained from films synthesied via method (2).

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Section: Introductionmentioning

confidence: 99%