Studies of Microbial Populations Artificially Localized in Vivo. Ii. Difference in Antityphoidal Activities of Chloramphenicol and Chlortetracycline 1

Werner, Charles A.; McDermott, Walsh; Adams, Carol; DuBois, Rebeckah

doi:10.1172/jci102944

Cited by 7 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Six years later, Metchnikoff inserted bacteria in collodion sacs into the abdominal cavities of guinea pigs (21). Others have used agar disks (29) or cellophane sacs (14) to localize purulent infection. Deysine et al (11) produced intra-abdominal abscesses using fresh rat feces, but the inoculum was not standardized and the abscess contents drained spontaneously, making it impossible to do long-term studies.…”

Section: %mentioning

confidence: 99%

Experimental Intra-Abdominal Abscesses in Rats: Development of an Experimental Model

et al. 1974

View full text Add to dashboard Cite

An animal model has been developed to study the evolution of intra-abdominal abscesses. Gelatin capsules containing pooled colonic contents and barium sulfate were prepared in an anaerobic chamber and implanted into the pelvic region of Wistar rats. The natural course of the ensuing disease was studied in various groups according to the source of the inoculum and sex of the recipient. Colonic contents derived from rats fed a grain diet produced a highly lethal disease with an 80% mortality rate for males and 100% for females. Most deaths occurred within 3 days of implantation, and autopsies showed generalized peritonitis. The addition of blood to the inoculum caused a rapidly fatal peritonitis in all animals. With an inoculum derived from meat-fed rats implanted in male recipients, there was a biphasic disease. Initially, there was peritonitis associated with 43% mortality. All animals that survived this acute period developed discrete intra-abdominal abscesses by the seventh postoperative day. The latter stage was characterized by an indolent course and progressive enlargement of abscesses.

show abstract

Section: %mentioning

confidence: 99%

Experimental Intra-Abdominal Abscesses in Rats: Development of an Experimental Model

et al. 1974

View full text Add to dashboard Cite

show abstract

“…In this way the use of the agar discs may help to explain certain discrepancies of drug action in vivo and in vitro. Such an investigation into the differences in antityphoidal action of chlortetracycline and chloramphenicol is the subject of a separate report (8). SUMMARY A method has been outlined whereby a bacterial population has been successfully localized in the peritoneal cavity of an animal host for varying periods of time.…”

Section: Differences In the Values Inmentioning

confidence: 99%