Studies of molecular factors predisposing for kidney stone disease and identification of molecular targets for its therapy and prophylaxis

Al-Shukri, Salman Khasunovich; Горбачев, М И; Landa, Sergey; Kovalenko, M. S.; Napalkova, O.; Yu, Emanuel

doi:10.1016/j.clinbiochem.2011.03.038

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“…One of the most important USD markers, the Tamm−Horsfield protein, was determined by the method of dynamic light scattering [47], which made possible the evaluation of the particles size. If the par ticles size attained 1 µm and higher, this was an evi dence of high USD probability.…”

Section: (5)mentioning

confidence: 99%

Determination of markers of the urinary stone disease

Yaroshenko

Карцова

2015

J Anal Chem

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546Urinary stone disease (USD) is a metabolic disor der characterized by the formation of concrements (from Latin concrementum, aggregate, union), i.e., heavy masses in kidney and organs of urinary system [1]. The history of the study of USD markers is very long [2], and the interest to this problem keeps steadily growing (Fig. 1). The major publications dealing with various aspects of USD fall to the highly specialized medical journals, such as Journal of Urology, Urology, and European Urology Supplements. The variety of scientific editions on the given problem underlines its urgency (Fig. 2).Almost 40% of urological diseases belong to USD and a trend to its growth is observed [1, 2]. The mech anism of the stone formation process was discussed in [3]. For quite a long time USD can proceed asymp tomatically. The emergence of USD at the early stage can be revealed using biochemical urine analysis [3][4][5]. Urine is a solution of a complex composition because of the elevated salt background and the pres Abstract-The capabilities of physicochemical methods (chromatographic, electrophoretic, potentiometric, and voltammetric) and also field test methods for the determination of the main markers of the urinary stone disease have been considered. The effect of various factors on the processes of stone formation has been dis cussed.

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Section: (5)mentioning

confidence: 99%