Studies of molecular pathways associated with blood neutrophil corticosteroid insensitivity in equine asthma

Dogaheh, Sheila Pourali; Boivin, R; Lavoie, Jean‐Pierre

doi:10.1016/j.vetimm.2021.110265

Cited by 2 publications

(2 citation statements)

References 193 publications

(253 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further studies regarding the oxidative status of the lung tissue after the administration of this supplement are needed to confirm this mechanism. Moreover, recently it has been demonstrated that the presence of high oxidative stress in the airways of the horse is one of the cause of the neutrophil corticosteroid insensitivity [ 17 ]; it could be hypothesized that the administration of products with antioxidant properties in association with standard therapies may be useful in the treatment of equine asthma.…”

Section: Discussionmentioning

confidence: 99%

“…This supplement aims to reduce airway inflammation, primarily modulating the oxidative stress. In fact, it has been reported that oxidative status plays a major role in sustaining equine asthma [ 13 , 14 , 15 ]; in particular, neutrophils are responsible for the production of reactive oxidant species (ROS) and their accumulation in the lower airway can result in a high level of oxidative stress, leading to an increase in the inflammation [ 16 , 17 ]. Moreover, it has been demonstrated that the administration of antioxidant substances such as Omega-3 fatty acids, in association with environmental changes, was effective in reducing airway inflammation in horses affected by equine asthma [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of the Administration of a Nutraceutical Supplement in Racehorses with Lower Airway Inflammation

Stucchi

Feudo

Stancari

et al. 2022

Animals

View full text Add to dashboard Cite

Mild–moderate equine asthma (MEA) is a chronic inflammatory disorder of the lower airways of the horse, characterized by tracheal mucus accumulation, cough and poor performance. The therapeutic approach is based on pharmacological treatment and environmental management. Moreover, the efficacy of the administration of antioxidant molecules has been reported. The aim of the present study was to evaluate the effect of the administration of a commercial nutraceutical supplement, composed of several herbal extracts, on lower airway inflammation in racehorses. Twelve Thoroughbreds affected by MEA were selected. All horses underwent a clinical examination with assignment of a clinical score, airway endoscopy and cytological examination of bronchoalveolar lavage fluid. In seven horses, the supplement was administered for 21 days in association with environmental changes, while in five horses only environmental changes were performed. All procedures were repeated at the end of the study. Data concerning the clinical score, the endoscopic scores and the cytology at the beginning and at the end of the study were statistically compared. Data showed a significant reduction (p < 0.0156) of the clinical score and a significant reduction (p < 0.0156) of the tracheal mucus score. The results showed the beneficial effect of the supplement on mild–moderate lower airway inflammation, probably due to its antioxidant activity.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of the Administration of a Nutraceutical Supplement in Racehorses with Lower Airway Inflammation

Stucchi

Feudo

Stancari

et al. 2022

Animals

View full text Add to dashboard Cite

show abstract

The Immune Mechanisms of Severe Equine Asthma—Current Understanding and What Is Missing

Simões

Batista

Tilley

2022

Animals

View full text Add to dashboard Cite

Severe equine asthma is a chronic respiratory disease of adult horses, occurring when genetically susceptible individuals are exposed to environmental aeroallergens. This results in airway inflammation, mucus accumulation and bronchial constriction. Although several studies aimed at evaluating the genetic and immune pathways associated with the disease, the results reported are inconsistent. Furthermore, the complexity and heterogeneity of this disease bears great similarity to what is described for human asthma. Currently available studies identified two chromosome regions (ECA13 and ECA15) and several genes associated with the disease. The inflammatory response appears to be mediated by T helper cells (Th1, Th2, Th17) and neutrophilic inflammation significantly contributes to the persistence of airway inflammatory status. This review evaluates the reported findings pertaining to the genetical and immunological background of severe equine asthma and reflects on their implications in the pathophysiology of the disease whilst discussing further areas of research interest aiming at advancing treatment and prognosis of affected individuals.

show abstract

Studies of molecular pathways associated with blood neutrophil corticosteroid insensitivity in equine asthma

Abstract: chevaux ont démontré une réponse similaire indiquant une réaction à la dexaméthasone et non liée à une inflammation asthmatique.

Cited by 2 publications

References 193 publications

Effect of the Administration of a Nutraceutical Supplement in Racehorses with Lower Airway Inflammation

Effect of the Administration of a Nutraceutical Supplement in Racehorses with Lower Airway Inflammation

The Immune Mechanisms of Severe Equine Asthma—Current Understanding and What Is Missing

Contact Info

Product

Resources

About