Studies of normal and neoplastic lymphocytes

Abstract

This brief review encapsulates a nearly 50-year career in biomedical research, primarily studying human leukemias and lymphomas, but also involving normal lymphocytes. Early observations included the feasibility of bone marrow transplantation (and related problems with graft-vs.-host reactions); the mitogenic effect of phytohemagglutinin (and resultant human lymphocyte culture techniques); and early cytogenetic findings in human leukemias, both lymphocytic and myeloid (including the Philadelphia chromosome). Subsequent studies of normal human lymphocytes have contributed to our enormously expanding knowledge of their basic biology, especially regulatory pathways, both extracellular and intracellular. Further work with human lymphoid neoplasms has helped extend the early chromosomal findings to the specific genes involved, including several regulating apoptosis; and also contributed to the concept of clonal evolution as a basic underlying mechanism of tumorigenesis in general. This career has covered a period of remarkable growth of knowledge concerning both normal and neoplastic lymphocytes, with potential for many important future clinical applications; it has been a privilege to participate.

Aldrin and Dieldrin: A Review of Research on Their Production, Environmental Deposition and Fate, Bioaccumulation, Toxicology, and Epidemiology in the United States

“…The U.S. EPA now does an commendable job of providing on the Internet access to air particle data for dieldrin, by geographic area, from each of their monitoring stations on a seasonal basis (43). USGS is now working on producing fish contaminant data in map format (181). USGS freshwater fish data, U.S. EPA aquatic data on the AQUIRE and ECOTOX databases and NOAA marine toxicity data could be substantially enhanced with more coordination among agencies (Table 8).…”

D-D and PLR, NLR combined forecasting first-line treatment: The short-term curative effect and prognosis of patients with SCLC

“…[ 27 ] Inhibitory lymphocytes secrete cytokines, and cytotoxicity induces cell death to suppress tumor growth and metastasis. [ 28 ] Therefore, lymphopenia may lower the malignant tumor immune response to promote tumor progression. The above results indicate that plasma D-D, PLR, and NLR can be helpful indicators for predicting the prognosis of SCLC patients.…”

Lectins and Tetrahymena – A review

“…Already at 1960, Nowell described the mitogenic activity of lectins [77]. Since this time, a plethora of papers justified this and lectins had been used as lymphocytic mitogens in immunological experiments.…”