Studies of normal and prematurely ruptured human amniotic membranes: Low calcium and magnesium in prematurely ruptured membranes

Kidroni, Gideon; Menczel, J; Ron, M.

doi:10.1515/jpme.1989.17.6.433

Jpme

1989

DOI: 10.1515/jpme.1989.17.6.433

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Studies of normal and prematurely ruptured human amniotic membranes: Low calcium and magnesium in prematurely ruptured membranes

Gideon Kidroni¹,

J Menczel²,

M. Ron³

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2000

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Permeability of fetal membranes to calcium and magnesium: possible role in preterm labour

Lemancewicz¹,

Laudańska²,

Laudański³

et al. 2000

Human Reproduction

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Calcium (Ca(2+)) and magnesium (Mg(2+)) are co-factors in the synthetic activity of a variety of enzymes and in the secretory process. Both the binding to fetal membranes and the diffusion through the membranes of these two cations could be important factors in the synthesis and/or action of prostaglandins and generation of nitric oxide (NO) which are believed to regulate myometrial activity particularly for the induction of labour. In the present study, the permeability to Ca(2+) and Mg(2+) of chorioamniotic membranes obtained from women who had undergone term or preterm labour was examined. Diffusion of Ca(2+) and Mg(2+) were measured using a system of Plexiglas chambers separated by the mounted fetal membrane. Permeability of Mg(2+) and Ca(2+) through fetal membranes was calculated using non-linear regression analysis. The data show highly significant differences in the diffusion of Ca(2+) and Mg(2+) across fetal membranes between preterm and term labour. Transport coefficient K for Ca(2+) was 0.203 h(-1) and 0. 0223 h(-1) in term and preterm labour respectively. The corresponding values for Mg(2+) were -0.017 h(-1) and 0.051 h(-1) respectively. It is proposed that a considerable reduction in Ca(2+) available to myometrium and placenta would result in down-regulation of nitric oxide synthase (NOS) activity and thereby a reduction in NO production. This together with an effect on intracellular Ca(2+) transport resulting from a reduced availability of Mg(2+) would lead to increased myometrial activity in preterm labour.

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Permeability of fetal membranes to calcium and magnesium: possible role in preterm labour

Lemancewicz¹,

Laudańska²,

Laudański³

et al. 2000

Human Reproduction

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show abstract

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Studies of normal and prematurely ruptured human amniotic membranes: Low calcium and magnesium in prematurely ruptured membranes

Cited by 1 publication

References 29 publications

Permeability of fetal membranes to calcium and magnesium: possible role in preterm labour

Permeability of fetal membranes to calcium and magnesium: possible role in preterm labour

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