Studies of Some Haemostatic Variables in Preeclamptic Women in Owerri, Imo State, Nigeria

Emeka-Obi, Obioma Raluchukwu; Ibeh, Nancy C; Obeagu, Emmanuel Ifeanyi; Okorie, Hope M.

doi:10.9734/jpri/2021/v33i42b32402

Cited by 6 publications

(4 citation statements)

References 14 publications

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“…Hydroxyurea has shown promise in reducing hemolysis, decreasing the frequency of vasoocclusive crises, and improving overall outcomes in non-pregnant individuals with sickle cell disease. While evidence regarding its safety during pregnancy is evolving, it may be considered in certain cases under close monitoring [89][90][91][92][93][94]. In cases of severe anemia or complications such as acute chest syndrome or stroke, red blood cell transfusions may be necessary.…”

Section: Best Practices In Managing Hemolysis In Pregnant Women With ...mentioning

confidence: 99%

Navigating Hemolysis in Expectant Mothers with Sickle Cell Anemia: Best Practices and Challenges

Obeagu,

Ugwu

et al. 2024

IAA-JAS

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Sickle cell anemia presents a multifaceted challenge in pregnancy due to increased hemolysis and associated complications for both mother and fetus. This review article aims to explore the nuanced landscape of managing hemolysis in expectant mothers with sickle cell anemia, focusing on best practices and challenges. The paper investigates the pathophysiological underpinnings of hemolysis in sickle cell anemia, emphasizing its exacerbation during pregnancy. It delves into preconception counseling and care, highlighting the significance of early intervention and comprehensive management strategies. Throughout gestation, continuous monitoring and tailored interventions are vital, necessitating close collaboration among multidisciplinary teams comprising hematologists, obstetricians, perinatologists, and genetic counselors. Best practices encompass various approaches, including hydroxyurea therapy and transfusion when warranted, although their safety during pregnancy remains a subject of ongoing research. The review navigates through challenges stemming from limited empirical data and ethical considerations, illuminating the complexities faced in decision-making regarding treatments that benefit both mother and fetus. In conclusion, this review underscores the critical need for a multidimensional approach in managing hemolysis in expectant mothers with sickle cell anemia. It accentuates the importance of individualized care, continuous research endeavors, and the development of evidence-based guidelines to address the intricate clinical landscape and improve outcomes for this vulnerable patient population. Keywords: Sickle Cell Anemia, Hemolysis, Pregnancy, Maternal Health, Fetal Health, Anemia

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Section: Best Practices In Managing Hemolysis In Pregnant Women With ...mentioning

confidence: 99%

Navigating Hemolysis in Expectant Mothers with Sickle Cell Anemia: Best Practices and Challenges

Obeagu,

Ugwu

et al. 2024

IAA-JAS

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“…The placenta, vital for fetal nourishment and oxygenation, is susceptible to oxidative stress due to its exposure to high oxygen levels and vulnerability to ROS-mediated damage. Oxidative stress in the placenta can impair nutrient transfer, compromise blood flow, and disrupt the balance of proinflammatory and anti-inflammatory mediators, potentially impacting fetal growth and development [64][65][66][67][68][69][70][71]. Maternal lifestyle choices, such as smoking, alcohol consumption, poor diet, and exposure to environmental toxins, can exacerbate oxidative stress during pregnancy, amplifying the risks of complications.…”

Section: Oxidative Stress In Pregnancymentioning

confidence: 99%

The Role of Antioxidants in Improving Pregnancy Outcomes

Obeagu,

Ugwu

et al. 2024

IAA-JAS

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Pregnancy is a physiologically demanding phase marked by profound changes that elevate oxidative stress levels, posing potential risks to maternal and fetal health. Oxidative stress, resulting from an imbalance between reactive oxygen species (ROS) production and antioxidant defense mechanisms, has been implicated in various pregnancy complications. Antioxidants, renowned for their ability to counteract ROS and mitigate cellular damage, have emerged as a potential intervention to ameliorate adverse outcomes during pregnancy. The paper highlights the physiological changes in pregnancy that contribute to heightened oxidative stress, emphasizing the link between oxidative stress and complications such as pre-eclampsia, gestational diabetes, preterm birth, and intrauterine growth restriction. This paper emphasizes the imperative for robust, well-designed clinical trials to elucidate the optimal timing, dosages, and formulations of antioxidants in pregnancy. It calls for a comprehensive approach to establish clear guidelines and recommendations for antioxidant supplementation. In conclusion, this review underscores the potential of antioxidants as a promising intervention to mitigate oxidative stress-related pregnancy complications. However, the inconclusive nature of current evidence necessitates further rigorous research endeavors. Through this exploration, it accentuates the urgency for standardized protocols, ethical considerations, and extensive clinical studies to unlock the full potential of antioxidants in improving maternal and fetal health outcomes during pregnancy. Keywords: Antioxidants, Pregnancy, Maternal Health, Fetal Health, Oxidative Stress, Reactive Oxygen Species (ROS), Preeclampsia, Gestational Diabetes, Fetal Development

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“…Metabolic alterations associated with neutrophil activation, such as increased oxidative stress markers or changes in lipid metabolism, might serve as indicative biomarkers of heightened inflammation. Analysis of biomarkers within the placental microenvironment or amniotic fluid, where inflammatory processes occur, could provide insights into local neutrophil-driven inflammation and its impact on pregnancy outcomes [81][82][83][84].…”

confidence: 99%

Neutrophil-Derived Inflammation and Pregnancy Outcomes

Obeagu,

Igwe

et al. 2023

NIJSES

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Inflammation, orchestrated by immune cells like neutrophils, plays a crucial role in maintaining homeostasis and protecting against pathogens. However, during pregnancy, the delicate balance of immune responses is paramount to support fetal development while safeguarding maternal health. Neutrophils, as pivotal contributors to the innate immune system, significantly influence the inflammatory milieu, yet excessive or dysregulated neutrophil-derived inflammation can impact pregnancy outcomes. This paper aims to dissect the multifaceted role of neutrophil-derived inflammation in shaping pregnancy outcomes. It delves into the mechanisms by which neutrophils orchestrate inflammatory responses during gestation and scrutinizes the implications of heightened inflammation on maternalfetal health. Specifically, it explores the association between increased neutrophil-driven inflammation and adverse outcomes such as preterm birth, preeclampsia, intrauterine growth restriction, and fetal developmental abnormalities. Examining the intricate balance between protective and detrimental roles of neutrophil-derived inflammation, this review assesses alterations in neutrophil functions, activation pathways, and the release of inflammatory mediators during normal and pathological pregnancies. Additionally, it evaluates potential regulatory mechanisms governing neutrophil-derived inflammation and identifies putative biomarkers indicative of heightened inflammatory responses linked to adverse pregnancy outcomes. The clinical implications of understanding the impact of neutrophil-derived inflammation on pregnancy outcomes are highlighted, emphasizing its significance in obstetric care, prenatal monitoring, and potential therapeutic interventions. Furthermore, this review delineates the NEWPORT INTERNATIONAL JOURNAL OF SCIENTIFIC AND EXPERIMENTAL SCIENCES (NIJSES) Volume 4 Issue 2 2023 ©NIJSES Publications Open Access ONLINE ISSN: 2992-5819 PRINT ISSN: 2992-6149 Obeagu et al., 2023 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited Page | 11 critical need for future research avenues focusing on molecular investigations, therapeutic modulation of neutrophildriven inflammation, and longitudinal studies to elucidate the long-term consequences on maternal and fetal wellbeing. In conclusion, unraveling the intricate interplay between neutrophil-derived inflammation and pregnancy outcomes is imperative. A deeper understanding of these interactions holds promise for informing clinical strategies, improving prenatal care, and ultimately optimizing maternal and fetal health.

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Studies of Some Haemostatic Variables in Preeclamptic Women in Owerri, Imo State, Nigeria

Cited by 6 publications

References 14 publications

Navigating Hemolysis in Expectant Mothers with Sickle Cell Anemia: Best Practices and Challenges

Navigating Hemolysis in Expectant Mothers with Sickle Cell Anemia: Best Practices and Challenges

The Role of Antioxidants in Improving Pregnancy Outcomes

Neutrophil-Derived Inflammation and Pregnancy Outcomes

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