Studies of Sulfobromophthalein Sodium (BSP) Metabolism in Man. I. In Normal Subjects and Patients with Hepatic Disease*

Schoenfield, Leslie J.; Foulk, William T.; Butt, Hugh R.

doi:10.1172/jci105016

Cited by 36 publications

(9 citation statements)

References 24 publications

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“…The existence of a rate-limited BSP transport mechanism in man was inferred from the achievement of a state in which the hepatic removal rate was independent of the absolute plasma concentration and related only to the rate of change of plasma concentration. Utilizing the constant-infusion technic, estimations of Tm in man, analogous to those in the dog, have been reported by Wheeler and his group and by workers in other laboratories as well (3,4).…”

mentioning

confidence: 95%

Studies of Sulfobromophthalein Sodium (BSP) Metabolism in Man. III. Demonstration of a Transport Maximum (Tm) for Biliary Excretion of BSP*

Schoenfield¹,

McGill²,

Foulk³

1964

J. Clin. Invest.

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mentioning

confidence: 95%

Studies of Sulfobromophthalein Sodium (BSP) Metabolism in Man. III. Demonstration of a Transport Maximum (Tm) for Biliary Excretion of BSP*

Schoenfield¹,

McGill²,

Foulk³

1964

J. Clin. Invest.

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“…In two subjects given a constant infusion of BSP immediately after a 34-hour period of fever, Tm and S were not altered (Table III), and the pattern of serum BSP conjugates was normal (2).…”

Section: Methodsmentioning

confidence: 94%

“…The methods used for measuring the fractional clearance (percentage disappearance rate, PDR), retention of dye at 60 minutes, and the proportion of serum BSP found in conjugated forms after a single intravenous * Submitted for publication December 23, 1963 injection of the dye have been described previously (2). Measurement of maximal biliary excretion (Tm) and relative hepatic storage capacity (S) for BSP during its constant infusion have been described also (2,3).…”

Section: Methodsmentioning

confidence: 99%

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Studies of Sulfobromophthalein Sodium (BSP) Metabolism in Man. II. The Effect of Artificially Induced Fever, Norethandrolone (Nilevar), and Iopanoic Acid (Telapaque)*

Schoenfield¹,

Foulk²

1964

J. Clin. Invest.

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The disappearance of sulfobromophthalein sodium (BSP) from the blood after its intravenous administration is a result of a complex of processes-hepatic uptake, storage, conjugation, and biliary excretion of the dye (1). Fever and the administration of anabolic steroids are among the factors that may influence the metabolism of BSP.In an attempt to determine the mechanisms of abnormal BSP retention induced by anabolic steroids and fever, we studied the effects of norethandrolone (Nilevar)' and of a brief period of artificially induced fever upon transport of the dye. During compilation of normal values for fractional clearance of BSP (2), a depression of this transport parameter was encountered in a woman ultimately given the diagnosis of "irritablebowel syndrome." When we learned that the gallbladder contrast medium, iopanoic acid (Telepaque),2 had been ingested on the evening before study, we added to the original plan an investigation of the effect of this commonly used cholecystographic material on BSP metabolism. Consequently, this paper reports observations on alteration of BSP transport induced by artificial fever and by two chemical agents, norethandrolone and iopanoic acid. MethodsThe methods used for measuring the fractional clearance (percentage disappearance rate, PDR), retention of dye at 60 minutes, and the proportion of serum BSP found in conjugated forms after a single intravenous * Submitted for publication December 23, 1963; accepted February 27, 1964. This investigation was supported in part by research grant AM-06908 from the National Institutes of Health. injection of the dye have been described previously (2). Measurement of maximal biliary excretion (Tm) and relative hepatic storage capacity (S) for BSP during its constant infusion have been described also (2, 3). In all instances normal healthy subjects were studied. Fever. Fractional clearance, retention of the dye at 60 minutes, and proportion of serum BSP in conjugates after a single intravenous injection of the dye were determined in six subjects. Each subject was studied on three occasions: at least one day before artificially induced fever, during the febrile episode, and the day after.The subject was placed supine in a moist-heat, feverproducing cabinet with only his-head exposed. About 1 hour was required to elevate the body temperature to 103°F as recorded by an electrical rectal thermometer. This temperature was maintained for the determination of fractional clearance and then permitted to drift back toward normal. In most instances the temperature was about 2°F above the base-line level at the time the 1-hour blood sample was drawn for determination of BSP retention.Tm and S for BSP were estimated in two additional healthy individuals with use of the constant-infusion technic of Wheeler, Meltzer, and Bradley (3). Fever was induced as described above, and rectal temperature greater than 1030 F was maintained for about 45 minutes, the total febrile period being about 3i hours. The constant infusion was started when the temperat...

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“…In patients with chronic liver disease the capacity of hepatocytes to excrete organic anions, such as bile salts, bilirubin, steroid hormones and certain drugs and dyes, is decreased [23,27,29], As a consequence, these substances and their metabolites may be retained in plasma and other tis sues. Except for bile acids, these organic anions share a common pathway of elimination from plasma into the bile which involves hepatic removal from plasma, hepatic storage, metabolic transformation and biliary excretion [12,30], Hepatic damage may interfere with any of these steps.…”

Section: Introductionmentioning

confidence: 99%

Bile Flow and Biliary Sulfobromophthalein Sodium Excretion in Rats with Liver Cirrhosis and Portacaval Shunt

Zsigmond¹,

Bodnár²,

Schaff³

et al. 1982

Eur Surg Res

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Inorder to study the combined effect of end-to-side portacaval shunt and chronic liver damage on biliary organic anion transport, the rat model of thioacetamide-induced chronic liver injury was utilized. Compared with sham-operated animals, bile flow and maximal biliary excretion (Tm) of sulfobromophthalein sodium (BSP) was decreased in rats 9 weeks after shunt operation. If rats with shunts were treated for 8 weeks with thioacetamide, an agent causing hepatic fïbrosis and pseudolobule formation, BSP transport from the hepatocyte into bile was further diminished. Compared with the shunted controls, the thioacetamide-treated rats with shunts had elevated serum bilirubin and alkaline phosphatase concentrations, and on electron microscopy their livers had dilated bile canaliculi with a decreased number of microvilli. Non-shunted rats treated with thioacetamide for 8 weeks had similar but less severe changes in the canalicular ultrastructure. Bile flow and BSP Tm were not influenced by thioacetamide treatment alone, perhaps due to the marked liver hypertrophy in these animals. These results indicate that canalicular active transport of organic anions is more sensitive to the effect of thioacetamide in animals with portacaval shunts than in those with sham operations. A similar impairment of hepatic organic anion handling by hepatotoxic compounds might be the consequence of portasystemic shunts in patients with liver cirrhosis.

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Studies of Sulfobromophthalein Sodium (BSP) Metabolism in Man. I. In Normal Subjects and Patients with Hepatic Disease*

Cited by 36 publications

References 24 publications

Studies of Sulfobromophthalein Sodium (BSP) Metabolism in Man. III. Demonstration of a Transport Maximum (Tm) for Biliary Excretion of BSP*

Studies of Sulfobromophthalein Sodium (BSP) Metabolism in Man. III. Demonstration of a Transport Maximum (Tm) for Biliary Excretion of BSP*

Studies of Sulfobromophthalein Sodium (BSP) Metabolism in Man. II. The Effect of Artificially Induced Fever, Norethandrolone (Nilevar), and Iopanoic Acid (Telapaque)*

Bile Flow and Biliary Sulfobromophthalein Sodium Excretion in Rats with Liver Cirrhosis and Portacaval Shunt

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