Studies of the antithrombotic effects of dextran 40 following microarterial trauma

Salemark, Lars; Wieslander, Jan B.; Dougan, Peter; Arnljots, Björn

doi:10.1016/0007-1226(91)90170-o

Cited by 36 publications

(19 citation statements)

References 14 publications

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“…Either PGE1 or dextran‐40 was used in our institution. Dextran has been shown to increase risk of anaphylaxis, pulmonary, and cerebral edema . Previous study by Riva et al concluded that antithrombotic therapy with PGE1 or dextran‐40 does not have any statistically significant influence on outcome of free tissue transfer in head and neck routine reconstructive surgery .…”

Section: Discussionmentioning

confidence: 99%

“…Dextran has been shown to increase risk of anaphylaxis, pulmonary, and cerebral edema. 51,52 Previous study by Riva et al concluded that antithrombotic therapy with PGE1 or dextran-40 does not have any statistically significant influence on outcome of free tissue transfer in head and neck routine reconstructive surgery. 53 Therefore, as mentioned in Result, we used the agents only in selected cases, such as patients of hypercoagulable state, or patients suffering from vascular compromise.…”

Section: Antithrombotic Agentsmentioning

confidence: 99%

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Free tissue transfers in head and neck reconstruction: Complications, outcomes and strategies for management of flap failure: Analysis of 2019 flaps in single institute

et al. 2013

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Background: Free tissue transfer has become the preferred option for complex reconstructions in head and neck cancer ablation. This study reviewed the surgical outcome and analyzed the evolution of microsurgical head and neck reconstruction over 20 years in single institute. Patients and Methods: A total of 1,918 patients underwent microsurgical head and neck reconstructions in 20-year period. The surgical outcome and complications among these 2,019 flaps (1,223 anterolateral thigh flaps, 372 fibula flaps, 353 radial forearm flaps, 12 jejunal flaps, and 59 others) were retrospectively reviewed and analyzed. Results: A total of 201 cases required emergent surgical reexploration and the overall flap success rate was 96.2%. Venous insufficiency was the most common cause for re-exploration. Other major complications included fistula formation (5.4%), partial flap necrosis (7.5%), and infection (17.8%). The fibula flap had frequent complications compared with soft tissue flaps. The familiarity to the ALT flap had minimized complications and allowed for widely versatile uses. Conclusion: Free tissue transfer is shown to be highly reliable option for head and neck reconstruction. For soft tissue defect, ALT flap is the first choice. Fibula flap is ideal for bone defect reconstruction. In case of complex composite defects, double flaps, which include ALT and fibula flaps could reconstruct bone and soft tissue defects simultaneously with high success rate. V C 2013 Wiley Periodicals, Inc. Microsurgery 34:339-344, 2014.

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Section: Discussionmentioning

confidence: 99%

Section: Antithrombotic Agentsmentioning

confidence: 99%

Free tissue transfers in head and neck reconstruction: Complications, outcomes and strategies for management of flap failure: Analysis of 2019 flaps in single institute

et al. 2013

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“…Many traumatic injuries or chronic inflammation are known to induce reactive thrombocytosis and may trigger platelet activation . In our series, eight patients suffered trauma of the upper and lower extremities.…”

Section: Discussionmentioning

confidence: 99%

The outcome of free tissue transfers in patients with hematological diseases: 20‐year experiences in single microsurgical center

et al. 2014

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“…Salemark et al 9 demonstrated improved immediate postoperative patency rates in rabbits, following dextran infusion. However, long-term effects remain suspect, 10 as does extrapolation of these studies to humans.…”

Section: Mode Of Actionmentioning

confidence: 98%

Dextrans in microsurgery: A review

Jallali

2003

Microsurgery

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Studies of the antithrombotic effects of dextran 40 following microarterial trauma

Cited by 36 publications

References 14 publications

Free tissue transfers in head and neck reconstruction: Complications, outcomes and strategies for management of flap failure: Analysis of 2019 flaps in single institute

Free tissue transfers in head and neck reconstruction: Complications, outcomes and strategies for management of flap failure: Analysis of 2019 flaps in single institute

The outcome of free tissue transfers in patients with hematological diseases: 20‐year experiences in single microsurgical center

Dextrans in microsurgery: A review

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