Studies of the Blood Chemistry in Thyroid Crisis

Studies on Amino Acid Metabolism. Ii. Blood Glycine and Total Amino Acids in Various Pathological Conditions, With Observations on the Effects of Intravenously Administered Glycine 1

“…This is in agreement with the blood amino N findings of Maddock et al (37) but is in contrast to the elevated values reported for the plasma, liver, and skeletal muscles of rats treated with thyroxine (35). The low glycine and low oral glycine tolerance test (16) in one case of hyperthyroidism with severe myopathy and creatinuria may be related to this complication.…”

Thyrotoxic Coma (Apathetic Crisis)

“…We also do not know whether there is any difference in the pathogenesis of the classical crisis and the rarer type presenting as a coma. The concentrations of the chief electrolytes of the blood were found by Maddock et al (1937) to be normal in the early stages of crisis. A decreased adrenal reserve occurs in hyperthyroidism as measured by the response to corticotrophin of eosinophils, ketosteroids, and formaldehydogenic steroids (Daughaday and Farr, 1951).…”

A Correlative Study of the Cardiac Output and the Hepatic Circulation in Hyperthyroidism 1

“…Clinical evidence of hepatic insufficiency is found in only the severest and most protracted cases. However, laboratory studies have demonstrated decreased bromsulphalein excretion (1), decreased hippuric acid synthesis (2), and diminished concentration of serum proteins particularly with reduction in serum albumen (3). Needle biopsy of the liver in a series of patients with usual degrees of thyrotoxicosis failed to demonstrate significant hepatic lesions (4).…”