Studies of the cavitational effects of clinical ultrasound by sonoluminescence: 4. The effect of therapeutic ultrasound on cells in monolayer culture in a standing wave field

Pickworth, M J W; Dendy, P P; Twentyman, P.R.; Leighton, Timothy G.

doi:10.1088/0031-9155/34/11/004

Cited by 28 publications

(12 citation statements)

References 4 publications

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“…Hence the above formulations provide a way of making worst-case estimates of the effect of the enhanced inertia: if such calculations show negligible effect then standard inertial terms can be used, but if not the implications need to be considered. Enhancement of the inertia could affect the measurement or exploitation of the bubble dynamics and resonance in a microfluidic device, 47,48 or in a chamber or Petri dish for cell treatment, 49,50 or in a glass=plastic capillary tube, or in a chamber on a microscope slide. This will reduce the resonance frequency of the, contrast agent 6,7 (confinement can also affect the damping) 51,52 , with commensurate implications for fitting parameters to free field models to match data obtained from confined bubbles.…”

Section: Discussionmentioning

confidence: 99%

The inertial terms in equations of motion for bubbles in tubular vessels or between plates

Leighton

2011

The Journal of the Acoustical Society of America

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Equations resembling the Rayleigh-Plesset and Keller-Miksis equations are frequently used to model bubble dynamics in confined spaces, using the standard inertial term RR+3R([middle dot]) (2)/2, where R is the bubble radius. This practice has been widely assumed to be defensible if the bubble is much smaller than the radius of the confining vessel. This paper questions this assumption, and provides a simple rigid wall model for worst-case quantification of the effect on the inertial term of the specific confinement geometry. The relevance to a range of scenarios (including bubbles confined in microfluidic devices; or contained in test chambers for insonification or imaging; or in blood vessels) is discussed.

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Section: Discussionmentioning

confidence: 99%

The inertial terms in equations of motion for bubbles in tubular vessels or between plates

Leighton

2011

The Journal of the Acoustical Society of America

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“…However, it would not be correct to equate the bubble activity in the cleaning bath with that which occurs in the UAS. The ultrasonic cleaning bath causes cavitation, whereby bubbles collapse under ultrasound to generate shock waves [27][28][29] and can also involute to form microjets [30,31], both of which can remove material from surfaces [32,33]. In contrast, the UAS system projects sound down a column of water [34] in order to excite surface waves [35][36][37] on the walls of microscopic bubbles on the surface to be cleaned.…”

Section: Cold Water Cleaning In An Ultrasonically Activated Strementioning

confidence: 99%

The acoustic bubble: Oceanic bubble acoustics and ultrasonic cleaning

Leighton¹

2015

Proceedings of Meetings on Acoustics

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Bubbles interact strongly with sound fields. Gas bubbles in the ocean generate sound as they are produced by breaking waves, rainfall, methane seeps, etc., and such emissions can be used to size and count the bubbles present. However after production, when the pulsations of such bubbles have damped away, they are silent unless re-excited. These, and other bubbles in the ocean that do not generally make significant passive sound emissions (such as those that appear through exsolution, and a range of biological processes including decomposition, photosynthesis, respiration and digestion) can still strongly influence applied sound fields through scattering, and changing the sound speed and absorption from that which would be expected in bubble-free water. This paper discusses how these phenomena might be associated with bubble netting by cetaceans. When driven with appropriate acoustic fields, bubbles can change their surrounding environment, and examples of this are shown through the generation of cleaning in an ultrasonically-activated stream of cold water, without additives.

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“…far-field acoustic emission) can, if interpreted carefully, be used to infer the quantitative degree of some other effect of cavitation (e.g. erosion, chemical processing, or luminescence) [89][90][91][92]. This approach has been exploited in SWL (see section 5.4).…”

Section: Cavitationmentioning

confidence: 99%

Lithotripsy

Leighton

Cleveland

2009

Proc Inst Mech Eng H

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Shock wave lithotripsy (SWL) is the process of fragmentation of renal or ureteric stones by the use of repetitive shock waves generated outside the body and focused onto the stone. Following its introduction in 1980, SWL revolutionized the treatment of kidney stones by offering patients a non-invasive procedure. It is now seen as a mature technology and its use is perceived to be routine. It is noteworthy that, at the time of its introduction, there was a great effort to discover the mechanism(s) by which it works, and the type of sound field that is optimal. Although nearly three decades of subsequent research have increased the knowledge base significantly, the mechanisms are still controversial. Furthermore there is a growing body of evidence that SWL results in injury to the kidney which may have long-term side effects, such as new onset hypertension, although again there is much controversy within the field. Currently, use of lithotripsy is waning, particularly with the advent of minimally invasive ureteroscopic approaches. The goal here is to review the state of the art in SWL and to present the barriers and challenges that need to be addressed for SWL to deliver on its initial promise of a safe, effective, non-invasive treatment for kidney stones.

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Studies of the cavitational effects of clinical ultrasound by sonoluminescence: 4. The effect of therapeutic ultrasound on cells in monolayer culture in a standing wave field

Cited by 28 publications

References 4 publications

The inertial terms in equations of motion for bubbles in tubular vessels or between plates

The inertial terms in equations of motion for bubbles in tubular vessels or between plates

The acoustic bubble: Oceanic bubble acoustics and ultrasonic cleaning

Lithotripsy

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