Studies of the Chick Edema Disease

Flick, D. F.; O'Dell, R. G.; Ross, V.

doi:10.3382/ps.0460186

Cited by 7 publications

(3 citation statements)

References 12 publications

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“…Higher intakes of the polychlorodibenzo-^-dioxins resulted in further reductions in the mean survival times. The data suggest that there may be a cumulative effect of ingested CEF compounds for the monkey as was reported previously for the chick (Flick et al, 1966(Flick et al, , 1967.…”

Section: Resultsmentioning

confidence: 55%

“…polyhalogenated organic compound which, when administered to chicks, will elicit some or all of the characteristic symptoms previously reported to describe the chick edema disease (Allen and Lalich, 1962;Allen, 1964;Allen and Carstens, 1966;Flick et al, 1965aFlick et al, ,b, 1966Flick et al, , 1967Wootton and Courchene, 1964). From the data on total dioxins ingested by chicks (Table 2), it is apparent that chicks respond to intakes of 9 to 23 fig.…”

Section: Resultsmentioning

confidence: 87%

“…Fat Sample No. 1 was the TFM used for both the previously reported chick feeding studies (Flick et al, 1966(Flick et al, , 1967 and the egg injection study (Flick et al, 1965a). Fat Sample No.…”

Section: Methodsmentioning

confidence: 99%

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Studies of the Chick Edema Disease

et al. 1973

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Based on recently obtained analytical information, calculations were made to ascertain the toxic effects of chick edema factor (CEF) preparations for the intact day-old chick, the developing chick embryo, and the monkey. Results indicate that CEF, principally polychlorodibenzo-^>-dioxins, elicits toxic responses in these experimental animals. For the intact chick, approximately 9 jug./chick of total dioxins containing 2-8 chlorine atoms/molecule are detectable. For the fertile chicken egg, less than 1.0 ng. is detectable. For the monkey, as little as 2.IS mg. ingested for 445 days, or less, elicits obvious adverse effects. It is postulated that ingestion of these types of compounds may be toxic for man. ABSTRACTThree trials were conducted comparing hatch weight as a percentage of egg weight with feed conversion of five selected lines (selected for low or high feed conversion) within two populations (broiler and randombred) of chickens. In each trial all eggs were weighed and divided into groups of 1 gram intervals within each line prior to incubation. At hatching all chicks were weighed, banded and their percent hatch weight determined.There were no differences in percent hatch weight of the lines that differed in feed conversion ratio in the broiler strains from 4-8 weeks of age or the randombred strains from 1-9 weeks of age. There was no correlation between percent hatch weight and feed conversion ratio within any of the lines and none at different ages. The percent hatch weight of the randombred strain ranged from 56-72% while that for the broiler strain ranged from 60-76%. The coefficient of variation was 4% in both strains.at NERL on May 31, 2015 http://ps.oxfordjournals.org/ Downloaded from

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Section: Resultsmentioning

confidence: 55%

Section: Resultsmentioning

confidence: 87%

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Chlorierte Biphenyle [MAK Value Documentation in German language, 1978]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 6. Lieferung, Ausgabe 1978 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmuster Metabolismus Erfahrungen beim Menschen Nichtberufliche Vergiftungen Berufliche Exposition Krebsbefunde Tierexperimentelle Befunde Akute Toxizität Chronische Toxizität Zur Frage eines MAK‐Wertes

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