Studies of the Coagulation of the Blood

Pickering, John W.; Hewitt, James Arthur

doi:10.1042/bj0160587

Cited by 12 publications

(5 citation statements)

References 2 publications

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“…The absence of antithrombic properties in unheated plasma and their appear ance only after heating to 60° supports the view, suggested by Pickering and Hewitt (15), that antithrombins are artificial products.…”

Section: Conclusion and Discussionsupporting

confidence: 65%

The development of blood plasma.—Part I. The genesis of coagulable material in embryo chicks

1925

Proc. R. Soc. Lond. B.

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Although much attention has been given to the embryonic development of blood corpuscles, the genesis of the coagulable constituents of the plasma has escaped notice. Knowledge of this subject appears to be limited to the observation of Boll (1) that the blood of chick embryos does not clot before the twelfth to fourteenth day of incubation; and of Emmel, Levison and Fisch (2) that the blood of late pig embryos clots more slowly than that of adult pigs. We shall describe the successive appearance in chick embryos of those constituents of the blood plasma which are associated respectively with the preservation of the fluidity of the blood and with its capacity to clot. We shall also briefly discuss the significance of the facts recorded.

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Section: Conclusion and Discussionsupporting

confidence: 65%

The development of blood plasma.—Part I. The genesis of coagulable material in embryo chicks

1925

Proc. R. Soc. Lond. B.

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“…Later, Popielski (39) suggested that the capillary endothelium participates in the secretion of anti-thrombin. Howell's views are, however, dissonant with the experiments of Pickering and Hewett (40), who found that large amounts of thrombin can be injected into the circulation of animals deprived of hepatic activity without causing intravascular clotting. (2) Nolf (41) maintained that thrombin is fixed by the capillary endothelium and thus cannot produce clots in vivo.…”

Section: Notes:-(1) Blood Was Obtained Through a Paraffined Cannula Fmentioning

confidence: 81%

Blood coagulation, anti-coagulants and hæmolysis

1924

Proc. R. Soc. Lond. B.

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Attention has recently been directed to the action of certain substances both in inhibiting the spontaneous clotting of blood and in affording protection against hæmolysis (Pickering and de Souza, 1). No systematic enquiry appears, however, to have been made into the possible influence of anticoagulants on the lysis of erythrocytes. We have found that most substances which restrain the clotting of blood are also anti-hæmolytic against heterologous sera, a specific hæmolysin, and cobra venom; also that certain agencies which restore the coagulability of blood after the influence of anti-coagulants will neutralise the anti-hæmolytic action of these substances.

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“…It was discovered by Howell at Johns Hopkins University around 1918 to 1922 and first used in a human patient in 1937. 13,14 Crafoord, a Swedish thoracic surgeon who had performed pulmonary embolectomy, recognized the potential of anticoagulation for treatment of pulmonary embolism as early as 1929. 14 However, reports of the use of heparin for treatment of thrombosis were rare until the 1940s.…”

Section: A Century Of Anticoagulants and Fibrinolyticsmentioning

confidence: 99%

A Brief Historical Perspective on Pulmonary Embolism

Morgan,

Saha

2024

Int J Angiol

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Pulmonary embolism is a major cause of mortality worldwide. In this historical perspective, we aim to provide an overview of the rich medical history surrounding pulmonary embolism. We highlight Virchow's first steps toward understanding the pathophysiology in the 1800s. We see how those insights inspired early attempts at intervention such as surgical pulmonary embolectomy and caval ligation. Those early interventions were refined and ultimately led to the development of inferior vena cava filters, the earliest clinical applications of anticoagulation, and even apparently disparate medical advances such as the successful development of cardiopulmonary bypass. We also see how the diagnosis of pulmonary embolism has evolved from rudimentary monitoring of vitals and symptoms to the development of evermore sophisticated tests such as contrast tomography angiography and echocardiography. Finally, we discuss current approaches to diagnosis, classification, and myriad treatments including anticoagulation, thrombolysis, catheter-directed interventions, surgical embolectomy, and extracorporeal membrane oxygenation guided by Pulmonary Embolism Response Teams.

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Studies of the Coagulation of the Blood

Cited by 12 publications

References 2 publications

The development of blood plasma.—Part I. The genesis of coagulable material in embryo chicks

The development of blood plasma.—Part I. The genesis of coagulable material in embryo chicks

Blood coagulation, anti-coagulants and hæmolysis

A Brief Historical Perspective on Pulmonary Embolism

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