Studies of the effects of hypothermia on regional myocardial blood flow and metabolism during cardiopulmonary bypass IV. Topical atrial hypothermia in normothermic beating hearts

Oxygenated machine perfusion at room temperature as an alternative for static cold storage in porcine donor hearts

“…Using MP, continuous temperature monitoring is an added value. Downregulation of metabolism in the present study was achieved by electrically arresting the heart 6 and cooling it to 21°C. This temperature was chosen as a point between both extremes of preservation temperature (0–8°C and normothermia).…”

“…The median coronary flow during evaluation ranged from 248 to 432 ml/min and 370-468 ml/min in the CS and MP groups, respectively (p-value between 0.548 and 0.841 at all evaluation time points). MP graft weight decreased by 10% [4][5][6][7][8][9][10][11][12] compared to weight after preservation, resulting in an overall increase of 43% compared to baseline. This was comparable to the 34% [27][28][29] increase of graft weight from baseline to end of the evaluation seen in CS (p = 0.151).…”

“…However, lowering the temperature below 15-20°C does not offer additional significant reductions in oxygen uptake during continuous oxygenated ESHP. 1,6,7 Also, deep hypothermia itself could lead to cell death, as it results in disruption of ion regulatory mechanisms and imbalances in ATP supply and demand. 8 To date, the majority of studies describing different temperatures during oxygenated ESHP focus on profound hypothermia (<10°C) and normothermia (>35°C).…”

The short-term and long-term effects of warm or tepid cardioplegia

“…Buckberg and colleagues 7 introduced warm blood cardioplegia in 1977. It was used as a method to decrease the reperfusion injury that occurred after crossclamp removal and was delivered as a terminal hot shot given approximately 3 to 5 minutes before aortic crossclamp removal.…”

Η Πληρης Επαναιματωση Του Μυοκαρδιου Με Αορτοστεφανιαια Παρακαμπτηρια Μοσχευματα Στην Αντιμετωπιση Της Στεφανιαιας Νοσου

“…Λόγω όμως της βραδυκαρδίας μειώνεται τελικά η κατανάλωση του 02. Καθώς κατεβαίνει η θερμοκρασία, μειώνεται η καρδιακή συχνότητα: όταν η θερ μοκρασία του μυοκαρδίου φθάσει στους 28oC εμφανίζεται αυτόματα κοιλιακή μαρμαρυγή (αν και μερικές φορές η καρ διά πάλλει με μικρή συχνότητα σε θερμοκρασία 20oC) (65). Η ηλεκτρική και μηχανική δραστηριότητα του μυοκαρδίου παύει ολοκληρωτικά όταν η θερμοκρασία του πέσει κάτω από τους160C.…”