Studies of the Female Bladder in Old Age

Brocklehurst, J.C.; Dillane, J.B.

doi:10.1159/000245005

Cited by 7 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Propantheline bromide (PB), one of the commonly used anticholinergic agents, has not been rigorously tested in a placebo controlled trial in the geriatric population with urinary incontinence and detrusor instability. Uncontrolled trials of propantheline bromide indicated that the drug may be effective for the treatment of incontinence in elderly patients [7].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of propantheline bromide in the treatment of geriatric patients with detrusor instability

Zorzitto

Jewett

Fernie

et al. 1986

Neurourology and Urodynamics

View full text Add to dashboard Cite

A placebo controlled, single-blind drug trial was designed to assess the efficacy of propantheline bromide (PB) in the treatment of urinary incontinence in geriatric institutionalized subjects with an uninhibited neurogenic bladder. Patients were randomly assigned to start PB 15 mg per 0s (PO) four times a day (QID), or placebo. Drug therapy was continued for 4 days after which a 3-day wash-out period was allowed before crossing over. Incontinence was recorded using an electronic monitor. If incontinence continued, the protocol was repeated at a 30-mg QID dose. Thirty-four patients completed the 15-mg protocol; no significant difference in continence was found between PB and placebo at this dose. Twenty-four patients completed the 30-mg dose, and a 17% improvement in continence was observed. This marginal clinical benefit was outweighed by the number of significant side effects. In conclusion, propantheline bromide was not a found to be a clinically useful agent for the rnanagment of incontinence in this group of institutionalized, elderly patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Effectiveness of propantheline bromide in the treatment of geriatric patients with detrusor instability

Zorzitto

Jewett

Fernie

et al. 1986

Neurourology and Urodynamics

View full text Add to dashboard Cite

show abstract

“…As we have found with other drugs used on the neurogenic bladder of old age (Brocklehurst and Dillane, 1967), not every person is benefited. There are some in whom no effect is observed.…”

Section: Side-effectsmentioning

confidence: 84%

Clinical Trial of Emepronium Bromide in Nocturnal Frequency of Old Age

Brocklehurst¹,

Dillane²,

Fry³

et al. 1969

BMJ

View full text Add to dashboard Cite

“…Reduction of the urinary output by posterior pituitary extract is not effective in controlling incontinence and does not improve the local anatomy (Dequeker 1965) Pharmacological blockade is beneficial in the treatment of elderly incontinent women many of whom have neurogenic lesions, but has no effect upon stress incontinence (Brocklehurst & Dillane 1967).…”

Section: Discussionmentioning

confidence: 99%

The Medical Treatment of Stress Incontinence

Jameson

1969

Int J Clinical Practice

View full text Add to dashboard Cite

Studies of the Female Bladder in Old Age

Cited by 7 publications

References 8 publications

Effectiveness of propantheline bromide in the treatment of geriatric patients with detrusor instability

Effectiveness of propantheline bromide in the treatment of geriatric patients with detrusor instability

Clinical Trial of Emepronium Bromide in Nocturnal Frequency of Old Age

The Medical Treatment of Stress Incontinence

Contact Info

Product

Resources

About