Studies of the Formation and Stability of Ezetimibe-Cyclodextrin Inclusion Complexes

Abstract

In the presented studies, the interactions between ezetimibe (EZE) and selected cyclodextrins were investigated. α-Cyclodextrin (αCD), β-cyclodextrin (βCD) and its modified derivatives, hydroxypropyl-β-cyclodextrin (HPβCD) and sulfobutylether-β-cyclodextrin (SBEβCD), were selected for the research. Measurements were carried out using calorimetric and spectroscopic methods. Additionally, the Hirshfeld surface and biochemical analysis were achieved. As a result of the study, the inclusion complexes with 1:1 stoichiometry were obtained. The most stable are the complexes of β-cyclodextrin and its derivatives. The comparison of βCD with its derivatives shows that the modifications have an affect on the formation of more durable and stable complexes.

Preparation, Optimization, and Characterization of Inclusion Complexes of Cinnamomum longepaniculatum Essential Oil in β-Cyclodextrin

“…While other bands can also be related: 2925 cm −1 for CH 2 groups stretching vibration, 1640 cm −1 for H-O-H bending vibration, 1156 cm −1 for C-O-C stretching vibration, 1079cm −1 for C-C stretching vibrations, and 1028 cm −1 for C-O stretching vibration. Similar results can be found reported previously [9,36].…”

UV-Vis Spectroscopic Characterization of β-Cyclodextrin-Vanillin Inclusion Complex

“…The second critical factor is the thermodynamic interactions between the three components, guest, CD and solvent, to form a more favorable driving force that causes the guest to enter into the CD cavity 1,15 . No covalent bonds are formed or broken during the complex formation, and the guest molecules in the complex are in equilibrium with free molecules in the media surrounding the CD 16,17 . The main forces for the complex formation of the host with the guest are; van der Waals interaction, hydrophobic interactions, hydrogen bonding, and electrostatic attraction 1,4,[18][19][20] .…”