Studies of the Hypothalamus-Pituitary-Adrenocortical System: An Example of Progress in Psychoneuroendocrinology

Holsboer, Florian; Bardeleben, U. von; Gerken, A.

doi:10.1007/978-3-642-70702-5_23

Cited by 6 publications

(1 citation statement)

References 143 publications

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“…a primary CRF hypersecretion) and inhibitory (i.e. negative feedback by short-loop ACTH and intermediate/delayed cortisol) influences (85). Therefore, the phenomenon of an increased corticotropic hormone escape from suppression by dexamethasone in melancholics can be explained by a breakthrough secretion driven by CRF and/or by a glucocorticoid receptor desensitization.…”

Section: Simultaneous Escape From Suppression By Dexamethasonementioning

confidence: 99%

A multivariate study of simultaneous escape from suppression by dexamethasone of urinary free cortisol, plasma cortisol, adrenocorticotropic hormone and β‐endorphin in melancholic patients

Maes¹,

Vandervorst

Suy³

et al. 1991

Acta Psychiatr Scand

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To investigate the relationships between pre- and postdexamethasone hypothalamic-pituitary-adrenal (HPA) axis functioning in depression, we measured the levels of baseline and postdexamethasone urinary free cortisol (UFC), plasma cortisol, adrenocorticotropic hormone (ACTH) and beta-endorphin. We found that dexamethasone significantly suppressed all hormone levels. All 4 postdexamethasone hormones--but not their baseline levels--were significantly higher in melancholic subjects than in minor and simple major depressives. We have accumulated evidence that the melancholic and minor depression groups form discrete classes in postdexamethasone HPA axis hormone levels; this supports the biological heterogeneity hypothesis of melancholia. We found that a combination of the postdexamethasone UFC and beta-endorphin values yielded the most significant diagnostic tool for melancholia. Our results suggest that the measurements of both hormones may constitute the most accurate index reflecting the HPA axis escape from suppression by dexamethasone in melancholia. By means of pathway analysis, we determined the causal relationships between age, dexamethasone circulating levels, diagnostic depression classification and the various baseline and postdexamethasone hormone values.

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Section: Simultaneous Escape From Suppression By Dexamethasonementioning

confidence: 99%

A multivariate study of simultaneous escape from suppression by dexamethasone of urinary free cortisol, plasma cortisol, adrenocorticotropic hormone and β‐endorphin in melancholic patients

Maes¹,

Vandervorst

Suy³

et al. 1991

Acta Psychiatr Scand

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Neuere biologische Untersuchungsverfahren und ihre Bedeutung für die Psychiatrie

Beckmann¹,

Lesch²

1989

Psychiatrie Der Gegenwart

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Psychoneuroendocrine research in depression

Lesch

Rupprecht

1989

J. Neural Transmission

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The rapid growth of fundamental research in neuroendocrinology includes advances in our understanding of the role of neurotransmitters in the control of hypophysiotropic neurons, the concept of neurosecretion, the portal circulation chemotransmitter hypothesis of anterior pituitary regulation, and the chemical structures of the hypophysiotropic hormones. These advances correspond to the emergence of psychoneurobiology, with the appreciation of the roles of neuropeptides, such as hypothalamic releasing and inhibiting hormones, their relevance to brain function and possible involvement in psychiatric disease, and their introduction into psychoneuroendocrinological studies. The subject of the present review is to summarize and integrate current knowledge of the neuroendocrinology of hypothalamic releasing and inhibiting hormones, to apply it to the understanding of the pathogenesis of depression, and to evaluate their relevance as psychoneuroendocrine research tools.

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Studies of the Hypothalamus-Pituitary-Adrenocortical System: An Example of Progress in Psychoneuroendocrinology

Cited by 6 publications

References 143 publications

A multivariate study of simultaneous escape from suppression by dexamethasone of urinary free cortisol, plasma cortisol, adrenocorticotropic hormone and β‐endorphin in melancholic patients

A multivariate study of simultaneous escape from suppression by dexamethasone of urinary free cortisol, plasma cortisol, adrenocorticotropic hormone and β‐endorphin in melancholic patients

Neuere biologische Untersuchungsverfahren und ihre Bedeutung für die Psychiatrie

Psychoneuroendocrine research in depression

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