Studies Of The Immune Response In Sendai Virus Infection Of Mice

Blandford, Gerald; Cureton, R. J. R.; Heath, R. B.

doi:10.1099/00222615-4-3-351

Cited by 24 publications

(28 citation statements)

References 5 publications

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“…Moreover, the intensity of lymphoid recruitment in the periphery of the airways varied a great deal from one strain to another. In this area, it has been said that greater local recruitment permits more effective viral eradication (7,13,35). However, in this experiment, it is clear that independently of the general histological profile, C57BL/6 and 129Sv exhibited higher peribronchial lymphoid recruitment, although they displayed the slowest viral clearance.…”

Section: Discussioncontrasting

confidence: 44%

“…When the compartmentation of the duration of each breathing cycle into its component inspiratory time (TI) and expiratory time (TE) was examined [via duty cycle (%Ti), Table S3], significant differences became apparent between strains: decrease of %Ti in 129Sv (on and after day 4), DBA/2 (on day 7), and C57BL/6 (on and after day 2) against stability in C3H/ HeN, SJL, and BALB/c.…”

Section: Resultsmentioning

confidence: 99%

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Sendai virus-induced alterations in lung structure/function correlate with viral loads and reveal a wide resistance/susceptibility spectrum among mouse strains

Faísca¹,

Anh²,

Desmecht³

2005

American Journal of Physiology-Lung Cellular and Molecular Phys

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The Paramyxoviridae family includes some of the most important and ubiquitous disease-causing viruses of infants and children, most of which cause significant infections of the respiratory tract. Evidence is accumulating in humans that genetic factors are involved in the severity of clinical presentation. As a first step toward the identification of the genes involved, this study was undertaken to establish whether laboratory mouse strains differ in susceptibility to Sendai virus, the murine counterpart of human type-1 parainfluenza virus which, historically, has been used extensively in studies that have defined the basic biological properties of paramyxoviruses in general. With this purpose in mind, double-chamber plethysmography data were collected daily for 7 days after inoculation of Sendai virus in six inbred strains of mice. In parallel, histological examinations and lung viral titration were carried out from day 5 to day 7 after inoculation. Pulmonary structure/function values closely reflected the success of viral replication in the lungs and revealed a pattern of continuous variation with resistant, intermediate, and susceptible strains. The results unambiguously suggest that BALB/c (resistant) and 129Sv (susceptible) strains should be used in crossing experiments aimed at identifying the genes involved in resistance to Paramyxoviridae by the positional cloning approach.

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Section: Discussioncontrasting

confidence: 44%

Section: Resultsmentioning

confidence: 99%

Sendai virus-induced alterations in lung structure/function correlate with viral loads and reveal a wide resistance/susceptibility spectrum among mouse strains

Faísca¹,

Anh²,

Desmecht³

2005

American Journal of Physiology-Lung Cellular and Molecular Phys

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“…This is more likely to have been due to an antibody response. Thus, Blandford and Heath (1972) demonstrated antibody in the lungs of Sendai virus-infected mice as early as the 3rd day of infection, and Mebus (1975) showed the disappearance of virus from ThiryVella loops of coronavirus-infected calves 5-6 days after infection, and the presence of antibody in the loops 7 days after infection.…”

Section: Rota Virus Infections In Piglets 331mentioning

confidence: 99%

Serial Studies of Virus Multiplication and Intestinal Damage in Gnotobiotic Piglets Infected with Rotavirus

Crouch

Woode

1978

Journal of Medical Microbiology

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“…The disease was related usually to shipping from a commercial facility and in one case occurred as an epizootic in a breeding colony. Experimentallyinduced Sendai virus infection has been studied by several investigators [l, 4, 5,14,[23][24][25]32,33]. The naturally-occurring and experimental diseases were characterized usually by low mortality, mild clinical signs, and quick recovery but occasionally by acute disease with high mortality.…”

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confidence: 99%

Naturally-Occurring Sendai Virus Infection of Athymic Nude Mice

et al. 1976

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Abstract. Nude (nulnu) mice, Balb/c-derived, responded to a naturally-occurring Sendai virus infection in a different manner than conventional mice. They developed a chronic debilitating disease and a persistent viral infection of the respiratory tract with intranuclear inclusion bodies in tracheal, bronchial and bronchiolar epithelial cells, laryngeal and tracheal glandular epithelium and in type I and I1 alveolar cells. The infection was identified by serologic and tissue culture studies, the mouse antibody production test and ultrastructural examination of pulmonary lesions. Phlebitis of pulmonary veins, suppurative rhinitis and otitis media accompanied the viral infection while some mice developed a secondary bronchopneumonia.

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Studies Of The Immune Response In Sendai Virus Infection Of Mice

Cited by 24 publications

References 5 publications

Sendai virus-induced alterations in lung structure/function correlate with viral loads and reveal a wide resistance/susceptibility spectrum among mouse strains

Sendai virus-induced alterations in lung structure/function correlate with viral loads and reveal a wide resistance/susceptibility spectrum among mouse strains

Serial Studies of Virus Multiplication and Intestinal Damage in Gnotobiotic Piglets Infected with Rotavirus

Naturally-Occurring Sendai Virus Infection of Athymic Nude Mice

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